Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0020 |
BAX |
BCL2-associated X protein |
581 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
The expression of Bcl-2 associated x protein (Bax) as markers of apoptosis. Hesperetin increased that of Bax in a dose-dependent manner at 48 h. |
17927510 |
MMP-AC0020 |
BAX |
BCL2-associated X protein |
581 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
Western blot results showed that expression level of Bax was increased in a dose-dependent manner. |
22194772 |
MMP-AC0020 |
BCL2 |
B-cell CLL/lymphoma 2 |
596 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
The expression of Bcl-2 as markers of apoptosis.Hesperetin decreased the expression of Bcl-2 in a dose-dependent manner at 48 . |
17927510 |
MMP-AC0020 |
BCL2L1 |
BCL2-like 1 |
598 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
It prevented the xenograft growth by down-regulating the expression of Bcl-x(L. |
22209285 |
MMP-AC0020 |
BCL2L1 |
BCL2-like 1 |
598 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
Western blot results showed that expression level of Bcl-xL was decreased in a dose-dependent manner. |
22194772 |
MMP-AC0020 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
Flavonoids caused downregulation of procaspase-3 which consequently increased the activity of caspase-3. |
22194772 |
MMP-AC0020 |
CCNB1 |
cyclin B1 |
891 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
It reduces the protein level of cyclin B1 in a dose-dependent manner.Decrease of cyclin B1 expression might be a molecular mechanism through which flavonoids induce G2/M arrest. |
22194772 |
MMP-AC0020 |
CCND1 |
cyclin D1 |
595 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
It prevented the xenograft growth by down-regulating the expression of cyclin D. |
22209285 |
MMP-AC0020 |
CCND1 |
cyclin D1 |
595 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
The expression of cyclin D was inhibited after 48 h of 50 µM hesperetin.Hesperetin induced a decrease in cyclinD and CDK4, together with an increase in p21Cip1 and p27Kip1 associated with CDK4. |
17927510 |
MMP-AC0020 |
CDC25C |
cell division cycle 25 homolog C (S. pombe) |
995 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
It reduces the protein level of cdc 25c in a dose-dependent manner.Decrease of cdc 25c expression might be a molecular mechanism through which flavonoids induce G2/M arrest. |
22194772 |
MMP-AC0020 |
CDK1 |
cyclin-dependent kinase 1 |
983 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
It reduces the protein level of cdc 2 in a dose-dependent manner.Decrease of cdc 2 expression might be a molecular mechanism through which flavonoids induce G2/M arrest. |
22194772 |
MMP-AC0020 |
CDK2 |
cyclin-dependent kinase 2 |
1017 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
Hesperetin treatment at high cncentration for 72 h resulted in a decrease in CDK2 and CDK4 together with cyclin D. A reduction in the expression of CDK2 and cyclin E was observed at the maximum concentration of 100 µM hesperetin for 72 h. |
17927510 |
MMP-AC0020 |
CDK4 |
cyclin-dependent kinase 4 |
1019 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
Hesperetin treatment resulted in a marked reduction in the expression of CDK4 in a dose-dependent manner after 48 and 72 h of treatment. |
17927510 |
MMP-AC0020 |
CDK4 |
cyclin-dependent kinase 4 |
1019 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
It prevented the xenograft growth by down-regulating the expression of CDK. |
22209285 |
MMP-AC0020 |
CDKN1A |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
1026 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
our data suggest for the first time that the regulation of CDK4 and p21Cip1 may participate in the anticancer activity pathway of hesperetin in MCF-7 cells. |
17927510 |
MMP-AC0020 |
CDKN1B |
cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
1027 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
hesperetin down-regulates the cyclin-dependent kinases (CDKs) and cyclins and upregulates p21Cip1 and p27Kip1 in cells treated with hesperetin for 48 h and 72 h. |
17927510 |
MMP-AC0020 |
CDKN1C |
cyclin-dependent kinase inhibitor 1C (p57, Kip2 |
1028 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
It prevented the xenograft growth by down-regulating the expression of p57Kip. |
22209285 |
MMP-AC0020 |
CYP19A1 |
cytochrome P450, family 19, subfamily A, polypeptide 1 |
1588 |
Breast adenocarcinoma |
MCF-7 |
5 µM |
- |
- |
- |
HSP inhibited aromatase enzyme activity and suppressed proliferation of MCF-7aro cells in vivo. |
22209285 |