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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0035 : Sanguinarine

 
Compound Name  :
Sanguinarine		  
  Compound Class  : Alkaloids  
  Synonyms  : pseudo-chelerythrine; pseudochelerythrine; sanguinarin; sanguinarine; sanguinarine chloride; sanguinarine hydroxide; sanguinarine nitrate; sanguinarine sulfate (1:1); sanguinarine sulfate (2:1); sanguiritrin; sangvinarin; Veadent; Viadent;

  
  Compound Extracted from  : Sanguinarine is extracted / reported from 2 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C20H14NO4+		  
  Molecular Weight  : 332.335  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 0  
  Hydrogen Bond Acceptor count  : 4  
  Rotational Bond count  : 0  
  TPSA  : 40.8  
  LogP Value  :

 4.4

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : No  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
5154		  
  Drugbank ID  : -  
  Super Natural  : 002447543  
  CTD  : C005705  
  HIT  : -  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/24300172

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0035 HL-60 Haematopoietic and Lymphoid tissue 0.9 µM (4hr) - - - 19346183

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0035 birc5a baculoviral IAP repeat-containing 5a 373110 Prostate Cancer DU145 - - - - The tumor growth in sanguinarine-treated group was suppressed starting at 31 days post cell inoculation and throughout the treatment period until 56 days when the mice were sacrificed . The levels of survivin protein expression in tumors were decreased in sanguinarine treatment group compared to the control group. These data demonstrated that sanguinarine was able to suppress the tumor growth of DU145 human prostate cancer cells. 21318089
MMP-AC0035 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 4790 Leukemia U-937 - - - - sanguinarine completely blocked the activation of NF-kB induced by TNF, IL-1, phorbol ester, and OA but not that activated by H2O2 and ceramide. 9374492
MMP-AC0035 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 4790 T cell leukemia Jurkat T - - - - sanguinarine completely blocked the activation of NF-kB induced by TNF, IL-1, phorbol ester, and OA but not that activated by H2O2 and ceramide. 9374492