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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0042 : Chrysin

 
Compound Name  :
Chrysin		  
  Compound Class  : Flavonoid  
  Synonyms  : chrysin; 480-40-0; 5,7-Dihydroxyflavone; Chrysine; 5,7-Dihydroxy-2-phenyl-4H-chromen-4-one; Crysin; 5,7-dihydroxy-2-phenylchromen-4-one; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-phenyl-; UNII-3CN01F5ZJ5; NSC-407436; FLAVONE, 5,7-DIHYDROXY-; EINECS 207-549-7; NSC407436; 5,7-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one; CHEMBL117; NSC 407436; 5,7-Dihydroxy-2-phenyl-chromen-4-one; BRN 0233276; 3CN01F5ZJ5; CHEBI:75095;

  
  Compound Extracted from  : Chrysin is extracted / reported from 2 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C15H10O4		  
  Molecular Weight  : 254.241  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 2  
  Hydrogen Bond Acceptor count  : 4  
  Rotational Bond count  : 1  
  TPSA  : 66.8  
  LogP Value  :

 2.1

  
 
Lipinski Rule of Five  :
No		  
  Ghose Filter  : No  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
5281607		  
  Drugbank ID  : -  
  Super Natural  : 000480400  
  CTD  : C043561  
  HIT  : C0370  
  NCI-60 GI50 data  :

 480-40-0

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/30016632

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0042 H295R Adrenal 7±3 µM - - - 15319488
MMP-AC0042 H295R Adrenal 7±3 µM - - - 15319488
MMP-AC0042 HeLa Cervix 13±2 µM - - - 16412650
MMP-AC0042 KB Nasopharyngeal 13±2 µM - - - 16412650
MMP-AC0042 B16-F0 Skin 22±2 µM - - - 16412650
MMP-AC0042 LM-3 Skin 17±6 µM - - - 16412650

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0042 CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1588 Adrenocortical Carcinoma H295R 7 µM - - - Chyrsin inhibited aromatase activity concentration dependently in H295R cells after a 24 h exposure.A key enzyme in the synthesis of estrogens from androgens is aromatase(cytochromeP45019;CYP19. 15319488
MMP-AC0042 NOS2 nitric oxide synthase 2, inducible 4843 Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus RAW264.7 - - - - Chrysin compounds do not have any nitrogen, but chrysin definitely inhibited iNOS enzyme catalysis as monitored by the hemoglobin oxidation assay. 14597150
MMP-AC0042 NOS2 nitric oxide synthase 2, inducible 4843 Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus RAW264.7 - - - - NO induction by LPS treatment in cultured Raw264.7 cells was prevented up to 80% by chrysin (at 50 M). 14597150