HOME
BROWSE
FLORA
CONTACT
Botanical Name Plant's Common Name Plant Family   

   MMP-AC0046 : Pristimerin

 
Compound Name  :
Pristimerin		  
  Compound Class  : Terpenoids  
  Synonyms  : Pristimerin; 1258-84-0; Celastrol-methylether; UNII-28ZK7PR57S; GNF-PF-476;

  
  Compound Extracted from  : Pristimerin is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C30H40O4		  
  Molecular Weight  : 464.6  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 1  
  Hydrogen Bond Acceptor count  : 4  
  Rotational Bond count  : 2  
  TPSA  : 63.6  
  LogP Value  :

 6.3

  
 
Lipinski Rule of Five  :
No		  
  Ghose Filter  : No  
  Veber Filter  : Yes  
  Muegge Filter  :

 No

  
 
PubChem CID  :
159516		  
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C009043  
  HIT  : -  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/22952775

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0046 PC-3 Prostate - - 0.23 µg/mL - 14640511
MMP-AC0046 PTX10 Ovary - - 0.076 µg/mL (6day) - 14640511
MMP-AC0046 1A9 Ovary - - 0.10 µg/mL (3day) - 14640511
MMP-AC0046 PTX10 Ovary - - 0.11 µg/mL (3day) - 14640511
MMP-AC0046 KB-VIN Nasopharyngeal - - 0.29 µg/mL - 14640511
MMP-AC0046 1A9 Ovary - - 0.11 µg/mL (6day) - 14640511
MMP-AC0046 KB Nasopharyngeal - - 0.10 µg/mL - 14640511
MMP-AC0046 A549 Lung - - 0.31 µg/mL - 14640511
MMP-AC0046 U-87-MG Brain - - 0.17 µg/mL - 14640511
MMP-AC0046 MCF-7 Breast - - 0.14 µg/mL - 14640511
MMP-AC0046 MCF-7 Breast 0.42-0.61 µMol/L - - - 16093444
MMP-AC0046 MDA-MB-231 Breast 0.42-0.61 µMol/L - - - 16093444

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0046 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 4790 Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus RAW264.7 - - - - Electrophoretic mobility shift assay EMSA, demonstrated a markedly reduced binding activity of NF-kappaB in nuclear extracts of pristimerin-treated cells. These results suggest that pristimerin inhibits the induction of inducible NO synthase by a mechanism which involves inhibition of NF-kappaB activation. 9384235
MMP-AC0046 NOS2 nitric oxide synthase 2, inducible 4843 Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus RAW264.7 - - - - Electrophoretic mobility shift assay EMSA. demonstrated a markedly reduced binding activity of NF-kappaB in nuclear extracts of pristimerin-treated cells. These results suggest that pristimerin inhibits the induction of inducible NO synthase. 9384235