HOME
BROWSE
FLORA
CONTACT
Botanical Name Plant's Common Name Plant Family   

   MMP-AC0086 : Epicatechin

 
Compound Name  :
Epicatechin		  
  Compound Class  : Flavonoid  
  Synonyms  : (-)-Epicatechin; 490-46-0; Epicatechin; L-Epicatechin; (-)-Epicatechol;

  
  Compound Extracted from  : Epicatechin is extracted / reported from 16 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C15H14O6		  
  Molecular Weight  : 290.27  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 5  
  Hydrogen Bond Acceptor count  : 6  
  Rotational Bond count  : 1  
  TPSA  : 110  
  LogP Value  :

 0.4

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
72276		  
  Drugbank ID  : DB12039  
  Super Natural  : -  
  CTD  : -  
  HIT  : C0136  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/29986831

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0086 L929 Connective tissue - 350±10 µM - - 9287415
MMP-AC0086 L929 Connective tissue - 300±7 µM - - 9287415

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0086 COX-1 cytochrome c oxidase subunit I 4512 Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus RAW264.7 7.5 µM - - - It inhibits cyclooxygenase 1 (Cox-1) activity and it is an anti-inflammatory mechanism. Phytochemistry Reviews 1: 369-377, 2002
MMP-AC0086 COX-1 cytochrome c oxidase subunit I 4512 - - 3.2 µM - - - Testing of compound was performed in-vivo. Compound is shown to have anticancer activity. 11962253
MMP-AC0086 COX-2 cytochrome c oxidase subunit II 4513 - - - - - - Testing of compound was performed in-vivo. Compound is shown have anticancer activity. 11962253
MMP-AC0086 NOS2 nitric oxide synthase 2, inducible 4843 Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus RAW264.7 >50 µM - - - Nitric oxide (NO) synthase (iNOS) and consequently, enhance the generation of NO. Generally, NO is an important signaling molecule, long-term elevated levels of NO, however, have been linked to early steps in carcinogenesis.It cause inhibition of lipopolysaccharide (LPS)-mediated induction of inducible nitric oxide synthase , which is an anti-inflammatory mechanis. Phytochemistry Reviews 1: 369-377, 2002
MMP-AC0086 NQO1 NAD(P)H dehydrogenase, quinone 1 1728 Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus RAW264.7 >50 µM - - - Compound induces the QR activity. Phytochemistry Reviews 1: 369-377, 2002
MMP-AC0086 ODC1 ornithine decarboxylase 1 4953 - - - - - - It is found that 80 g of (-)-Epicatechin in 2 mg of GTP showed 17% of inibition on TPA-induced Epidermal ODC activity.The topical application of 4 µmol of (-)-Epicatechin in 0.2 ml acetone/animal 30 min prior to the topical application of 5 µg TPA in 0.2 ml acetone resulted in the significant inhibition of TPA-induced epidermal ODC activity. 1617628