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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0164 : Aloe-emodin

 
Compound Name  :
Aloe-emodin		  
  Compound Class  : Polycyclic aromatic natural product  
  Synonyms  : Aloe-emodin; Aloe emodin; 481-72-1; Aloeemodin; Aloe-emodine; Rhabarberone;

  
  Compound Extracted from  : Aloe-emodin is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C15H10O5		  
  Molecular Weight  : 270.24  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 3  
  Hydrogen Bond Acceptor count  : 5  
  Rotational Bond count  : 1  
  TPSA  : 94.8  
  LogP Value  :

 1.8

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
10207		  
  Drugbank ID  : -  
  Super Natural  : 000481721  
  CTD  : -  
  HIT  : C0324  
  NCI-60 GI50 data  :

 481-72-1

  
 
Reference(s)  :
https://pubchem.ncbi.nlm.nih.gov/compound/10207

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0164 HeLa Cervix - - 40 µM - 10850417
MMP-AC0164 CEM Haematopoietic and Lymphoid tissue - - 100 µM - 10850417

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0164 MAPK1 mitogen-activated protein kinase 1 5594 Rat Glioma C6 - - - - Compound significantly reduced the level of phospho-ERK in C6 cells, as determined by cell-based ELISA. 15747063
MMP-AC0164 MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 4313 Colorectal cancer WiDr - - - - The activation of MMP-2 was subsequently reduced to the basal levels on incubation with Aloe-emodin, whereas the activation of MMP-9 was brought down by 2.8-fold on treatment with Aloe-emodin 22227305
MMP-AC0164 MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 4318 Colorectal cancer WiDr - - - - The activation of MMP-2 was subsequently reduced to the basal levels on incubation with Aloe-emodin, whereas the activation of MMP-9 was brought down by 2.8-fold on treatment with Aloe-emodin. 22227305
MMP-AC0164 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 4790 Colorectal cancer WiDr - - - - Aloe-emodin was shown to inhibit the DNA binding activity of NF-kappaB. 22227305