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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0176 : Chebulinic acid

 
Compound Name  :
Chebulinic acid		  
  Compound Class  : Tannin  
  Synonyms  : 18942-26-2; NSC69862; CHEBI:3584; AC-31408;

  
  Compound Extracted from  : Chebulinic acid is extracted / reported from 3 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C41H32O27		  
  Molecular Weight  : 956.7  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 13  
  Hydrogen Bond Acceptor count  : 27  
  Rotational Bond count  : 12  
  TPSA  : 447  
  LogP Value  :

 0.7

  
 
Lipinski Rule of Five  :
No		  
  Ghose Filter  : No  
  Veber Filter  : No  
  Muegge Filter  :

 No

  
 
PubChem CID  :
72284		  
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C103481  
  HIT  : C0197  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://pubchem.ncbi.nlm.nih.gov/compound/72284

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0176 HOS-1 Bone 53.2±0.16 µM - - - 12127233

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0176 GATA1 GATA binding protein 1 2623 Leukemia K-562 - - - - In K562 cells only treated with chebulinic acid 50 micromol/L for 72 h, the levels of gamma-globin and PBGD mRNA as well that of mRNA for erythroid transcription factor NF-E2 were obviously decreased, the level of mRNA for GATA-1,another erythroid transcription factor, was slightly reduced, the level of mRNA for GATA-2, a megakaryocytic transcription factor, was obviously induce. 14769215
MMP-AC0176 GATA2 GATA binding protein 2 2624 Leukemia K-562 - - - - In K562 cells only treated with chebulinic acid 50 micromol/L for 72 h, the levels of gamma-globin and PBGD mRNA as well that of mRNA for erythroid transcription factor NF-E2 were obviously decreased, the level of mRNA for GATA-1,another erythroid transcription factor, was slightly reduced, the level of mRNA for GATA-2, a megakaryocytic transcription factor, was obviously induce. 14769215
MMP-AC0176 HBG1 hemoglobin, gamma A 3047 Leukemia K-562 - - - - In K562 cells only treated with chebulinic acid 50 micromol/L for 72 h, the levels of gamma-globin and PBGD mRNA as well that of mRNA for erythroid transcription factor NF-E2 were obviously decreased, the level of mRNA for GATA-1,another erythroid transcription factor, was slightly reduced, the level of mRNA for GATA-2, a megakaryocytic transcription factor, was obviously induce. 14769215
MMP-AC0176 HMBS hydroxymethylbilane synthase 3145 Leukemia K-562 - - - - In K562 cells only treated with chebulinic acid 50 micromol/L for 72 h, the levels of gamma-globin and PBGD mRNA as well that of mRNA for erythroid transcription factor NF-E2 were obviously decreased, the level of mRNA for GATA-1,another erythroid transcription factor, was slightly reduced, the level of mRNA for GATA-2, a megakaryocytic transcription factor, was obviously induce. 14769215
MMP-AC0176 NFE2 nuclear factor (erythroid-derived 2), 45kDa 4778 Leukemia K-562 - - - - In K562 cells only treated with chebulinic acid 50 micromol/L for 72 h, the levels of gamma-globin and PBGD mRNA as well that of mRNA for erythroid transcription factor NF-E2 were obviously decreased, the level of mRNA for GATA-1,another erythroid transcription factor, was slightly reduced, the level of mRNA for GATA-2, a megakaryocytic transcription factor, was obviously induce. 14769215