HOME
BROWSE
FLORA
CONTACT
Botanical Name Plant's Common Name Plant Family   

   MMP-AC0178 : Cinnamaldehyde

 
Compound Name  :
Cinnamaldehyde		  
  Compound Class  : Organic chemical  
  Synonyms  : cinnamaldehyde; trans-Cinnamaldehyde; 104-55-2; 14371-10-9; Cinnamic aldehyde;

  
  Compound Extracted from  : Cinnamaldehyde is extracted / reported from 3 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C9H8O		  
  Molecular Weight  : 132.16  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 0  
  Hydrogen Bond Acceptor count  : 1  
  Rotational Bond count  : 2  
  TPSA  : 17.1  
  LogP Value  :

 1.9

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : No  
  Veber Filter  : Yes  
  Muegge Filter  :

 No

  
 
PubChem CID  :
637511		  
  Drugbank ID  : DB14184  
  Super Natural  : 000104552  
  CTD  : C012843  
  HIT  : C0369  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://pubchem.ncbi.nlm.nih.gov/compound/637511

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0178 HL-60 Haematopoietic and Lymphoid tissue 32.62 µg/ml - - - 20359874
MMP-AC0178 Hep G2 Liver 9.76±0.67 µM - - - 20038571

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0178 BAX BCL2-associated X protein 581 Hepatoma Hep G2 - - - - Results displayed that pre-incubation the Hep G2 cells with 30 µM PFTalpha alone and 30 µM PFTalpha + 30µM Cin effectively inhibited the expression of Bax, p53 and CD95, as well as the cleavage of PARP.These pretreatment also prevented the downregulation of Bcl-XL in cells. 20038571
MMP-AC0178 BCL2L1 BCL2-like 1 598 Hepatoma Hep G2 - - - - Results displayed that pre-incubation the Hep G2 cells with 30 µM PFTalpha alone and 30 µM PFTalpha + 30µM Cin effectively inhibited the expression of Bax, p53 and CD95, as well as the cleavage of PARP.These pretreatment also prevented the downregulation of Bcl-XL in cells. 20038571
MMP-AC0178 FAS Fas (TNF receptor superfamily, member 6) 355 Hepatoma Hep G2 - - - - Results showed that compound caused a time dependent increase in the CD95 (APO-1) protein expression in HepG2 cell. 20038571
MMP-AC0178 PARP1 poly (ADP-ribose) polymerase 1 142 Hepatoma Hep G2 - - - - PARP cleavage was determined by immunoblotting analysis. Results showed that PARP proform (molecular mass, 116 kDa) was cleaved to give an 85kDa fragment in Cin-treated cells at 12 and 24h after treatments. 20038571
MMP-AC0178 TP53 tumor protein p53 7157 Hepatoma Hep G2 - - - - Compound did cause an increase in the level of p53 as Hep G2 cells contain wild-type p5. 20038571