Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0181 |
CASP3 |
Caspase 3, apoptosis-related cysteine peptidase |
836 |
Colon Cancer |
HT-29 |
- |
- |
- |
- |
After the treatments of different doses of Epigallocatechin gallate (EGCG) , the induction of caspase-3 activity in HT-29 cells was consistent with the results shown in DAPI staining and DNA fragmentation experiments. 100 mM of EGCG led to ~8-fold induction of caspase-3 activity after 24 h treatment. |
12819184 |
MMP-AC0181 |
CASP9 |
caspase 9, apoptosis-related cysteine peptidase |
842 |
Colon Cancer |
HT-29 |
- |
- |
- |
- |
During the 24 h period, the activity of caspase-9 was consistently increased with the treatment of Epigallocatechin gallate (EGCG). |
12819184 |
MMP-AC0181 |
MAPK1 |
mitogen-activated protein kinase 1 |
5594 |
Colon Cancer |
HT-29 |
- |
- |
- |
- |
ERK was phosphorylated and activated time-dependently in HT-29 cells after Epigallocatechin gallate (EGCG) treatments. |
12819184 |
MMP-AC0181 |
MAPK1 |
mitogen-activated protein kinase 1 |
5594 |
Colon Cancer |
HT-29 |
- |
- |
- |
- |
p38 was phosphorylated and activated time-dependently in HT-29 cells after EpigallMAPK8ocatechin gallate (EGCG) treatments. |
12819184 |
MMP-AC0181 |
MAPK8 |
mitogen-activated protein kinase 8 |
5599 |
Colon Cancer |
HT-29 |
- |
- |
- |
- |
JNK was phosphorylated and activated time-dependently in HT-29 cells after Epigallocatechin gallate (EGCG) treatments |
12819184 |
MMP-AC0181 |
PRKAB1 |
protein kinase, AMP-activated, beta 1 non-catalytic subunit |
5564 |
Colon Cancer |
HT-29 |
- |
- |
- |
- |
EGCG activated AMPK in a dose-dependent manner as shown by the increased phosphorylation of ACC (acetyl-CoA carboxylase) and the elevation of AMPK expression. |
16797120 |
MMP-AC0181 |
SLC2A1 |
Solute carrier family 2 |
6513 |
Colon Cancer |
HT-29 |
- |
- |
- |
- |
Epigallocatechin gallate distinctively reduced mRNA levels of Glut-1 |
16797120 |
MMP-AC0181 |
VEGFA |
Vascular endothelial growth factor A |
7422 |
Colon Cancer |
HT-29 |
- |
- |
- |
- |
Epigallocatechin gallate distinctively reduced mRNA levels of VEGF genes. |
16797120 |