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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0184 : Falcarindiol

 
Compound Name  :
Falcarindiol		  
  Compound Class  : Aliphatic natural products  
  Synonyms  : Falcarindiol; 225110-25-8; (+)-(3R,8S)-Falcarindiol; (3R,8S)-Falcarindiol; (3S,8S)-Falcarindiol;

  
  Compound Extracted from  : Falcarindiol is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C17H24O2		  
  Molecular Weight  : 260.4  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 2  
  Hydrogen Bond Acceptor count  : 2  
  Rotational Bond count  : 9  
  TPSA  : 40.5  
  LogP Value  :

 4.4

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : No  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
5281148		  
  Drugbank ID  : -  
  Super Natural  : 055297875  
  CTD  : C034379  
  HIT  : -  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://pubchem.ncbi.nlm.nih.gov/compound/5281148

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0184 Colo-205 Colon 0.819 µg/ml - - - 10230514
MMP-AC0184 K-562 Haematopoietic and Lymphoid tissue 0.577 µg/ml - - - 10230514

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0184 BAX BCL2-associated X protein 581 Breast adenocarcinoma MCF-7 - - - - Falcarindiol was found to have anti-proliferative effect against MCF-7 human breast cancer cells by induction of a G0/G1 cell cycle block of the cells, with an IC50 value of 35.67 µM. Falcarindiol induced apoptosis through strongly increased mRNA expression of Bax. 22019572
MMP-AC0184 BCL2 B-cell CLL/lymphoma 2 596 Breast adenocarcinoma MCF-7 - - - - Falcarindiol was found to have anti-proliferative effect against MCF-7 human breast cancer cells by induction of a G0/G1 cell cycle block of the cells, with an IC50 value of 35.67 µM.falcarindiol induced apoptosis through slightly reduced Bcl-2 mRNA levels in a dose dependent manner. 22019572
MMP-AC0184 TP53 tumor protein p53 7157 Breast adenocarcinoma MCF-7 - - - - Falcarindiol was found to have anti-proliferative effect against MCF-7 human breast cancer cells by induction of a G0/G1 cell cycle block of the cells, with an IC50 value of 35.67 µM.falcarindiol induced apoptosis through strongly increased mRNA expression of p53 in a dose dependent manner. 22019572