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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0187 : Gallic Acid

 
Compound Name  :
Gallic Acid		  
  Compound Class  : Simple aromatic natural product  
  Synonyms  : Gallic acid; 3,4,5-Trihydroxybenzoic acid 149-91-7 gallate; gallate;Benzoic acid, 3,4,5-trihydroxy-;Gallic acid, tech.;Pyrogallol-5-carboxylic acid;3,4,5-Trihydroxybenzoate;Gallic acid polymer;GALOP;

  
  Compound Extracted from  : Gallic Acid is extracted / reported from 36 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C7H6O5		  
  Molecular Weight  : 170.12  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 4  
  Hydrogen Bond Acceptor count  : 5  
  Rotational Bond count  : 1  
  TPSA  : 98  
  LogP Value  :

 0.7

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : No  
  Veber Filter  : Yes  
  Muegge Filter  :

 No

  
 
PubChem CID  :
370		  
  Drugbank ID  : -  
  Super Natural  : 000149917  
  CTD  : D005707  
  HIT  : C0001  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://pubchem.ncbi.nlm.nih.gov/compound/370

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0187 MCF-7 Breast >50 µg/ml - - - 19731038
MMP-AC0187 Caco-2 Colon 2.6±0.08 µg/ml - - - 19731038
MMP-AC0187 ACHN Kidney 20.7±2.1 µg/ml - - - 19731038
MMP-AC0187 A549 Lung >50 µg/ml - - 19731038
MMP-AC0187 COR-L23 Lung 4.6±0.005 µg/ml - - - 19731038
MMP-AC0187 LNCaP Prostate >50 µg/ml - - - 19731038
MMP-AC0187 A-375 Skin >50 µg/ml - - - 19731038
MMP-AC0187 C32 Skin >50 µg/ml - - - 19731038

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0187 AKT1 v-akt murine thymoma viral oncogene homolog 1 207 Gastric Cancer AGS - - - - The protein levels of AKT-1, decreased after AGS cell treated with gallic acid. 20600540
MMP-AC0187 AKT1 v-akt murine thymoma viral oncogene homolog 1 207 Gastric Cancer AGS - - - - The protein levels of P-AKT, decreased after AGS cell treated with gallic acid. 20600540
MMP-AC0187 CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 998 Gastric Cancer AGS - - - - After treatment of AGS cells witht different concentrations of gallic acid (2.0-3.5 µM) for 48 h, the results showed protein levels of cdc42 decreased in a dose-dependent manner. 20600540
MMP-AC0187 IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 9641 Gastric Cancer AGS - - - - AGS cells were treated with or without different concentrations of gallic acid (2.0-3.5 µM) for 48 h. the protein levels of IjB increased in a dose-dependent manner. 20600540
MMP-AC0187 MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 4313 Gastric Cancer AGS - - - - MMP-9 activity was markedly reduced with GA. The inhibitory effects were more significant at concentrations of 2.5 and 3.5µM.GA presents a strong suppression on AGS cell growth and MMP secretion. GA possesses almost 600 times higher suppressive effect on MMP secretion than Caffic acid and Protocatechuic acid. 20600540
MMP-AC0187 MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 4318 Gastric Cancer AGS - - - - MMP-2 activity was markedly reduced with GA. The inhibitory effects were more significant at concentrations of 2.5 and 3.5µM.GA presents a strong suppression on AGS cell growth and MMP secretion. GA possesses almost 600 times higher suppressive effect on MMP secretion than Caffic acid and Protocatechuic acid. 20600540
MMP-AC0187 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 4790 Gastric Cancer AGS - - - - Gallic acid inhibited the migration of AGS cells by inhibition NFKB activity and downregulation of PI3 K/AKT pathway. 20600540
MMP-AC0187 PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 5290 Gastric Cancer AGS - - - - The protein levels of PI3K, decreased after AGS cell treated with gallic acid. 20600540
MMP-AC0187 RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 5879 Gastric Cancer AGS - - - - After treatment of AGS cells witht different concentrations of gallic acid (2.0-3.5 µM) for 48 h, the results showed showed protein levels of Rac1 decreased in a dose-dependent manner. 20600540
MMP-AC0187 RHOA ras homolog family member A 387 Gastric Cancer AGS - - - - After treatment of AGS cells witht different concentrations of gallic acid (2.0-3.5 µM) for 48 h, the results showed showed protein levels of RhoA decreased in a dose-dependent manner. 20600540
MMP-AC0187 RHOB ras homolog family member B 388 Gastric Cancer AGS - - - - After treatment of AGS cells witht different concentrations of gallic acid (2.0-3.5 µM) for 48 h, the results showed showed protein levels of RhoB increased in a dose-dependent manner. 20600540
MMP-AC0187 SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 6818 Hepatoma Hep G2 - - -- - Gallic acid was found to increase PST-P activity. Gallic acid inducing PST-P activity, in a concentration-dependent manner, in concentrations of 10-50 µM, with a maximum of 4-5-fold induction. Gallic acid, a trihydroxybenzoic acid, has been found to cause a significant increase in the activity of PST-P. PST-P mRNA expression was induced markedly by gallic acid, in a dose-responsive manner. A maximum of 4.6-fold mRNA expression was observed at 50 µM. A marked induction of PST-P mRNA expression, by gallic acid, was observed after 6 h of exposure; maximum induction of PST-P mRNA expression was observed at 12 h after the addition of 50 µM gallic acid. PST-P protein was markedly induced by gallic acid, in a dose response manner, at concentrations of 10-50 µM. A maximum of 3.5-fold induction was observed at 50 µM.Significant (p <0.05) induction of PST-P protein was observed 24 h after the addition of 50 µM gallic acid. The enhanced PST-P protein expression in HepG2 cells, after treatment with gallic acid, corresponded to the induction of PST-P activity , suggesting that the observed induction of PST-P activity, by gallic acid, is due to increased PST-P protein synthesis, through activation of gene transcription. 15941313