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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0202 : Morusin

 
Compound Name  :
Morusin		  
  Compound Class  : Flavonoid  
  Synonyms  : Morusin 62596-29-6 Mulberrochromene TCMDC-124149 2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one

  
  Compound Extracted from  : Morusin is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C25H24O6		  
  Molecular Weight  : 420.5  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 3  
  Hydrogen Bond Acceptor count  : 6  
  Rotational Bond count  : 3  
  TPSA  : 96.2  
  LogP Value  :

 5.5

  
 
Lipinski Rule of Five  :
NO		  
  Ghose Filter  : YES  
  Veber Filter  : YES  
  Muegge Filter  :

 NO

  
 
PubChem CID  :
5281671		  
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C057451  
  HIT  : -  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://pubchem.ncbi.nlm.nih.gov/compound/5281671#section=Chemical-and-Physical-Properties

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0202 MCF-7 Breast 12.7±2.1 µM - - - 18485277
MMP-AC0202 HT-29 Colon 6.1±0.3 µM - - - 18485277
MMP-AC0202 Hep-3B Liver 8.5±1.1 µM - - - 18485277

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0202 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Colon Cancer HT-29 - - - - Increase in the active form of Caspase-3 was also observed at 12-72 h. PARP is a substrate of caspase-3 and Active caspase-3 can also catalyze DFF-45 and DFF-35. Cleavage of PARP and translocation of DFF-40 in nuclei indicate the activity of caspase-3 and also suggest the results of DNA fragmentation. 18485277
MMP-AC0202 CASP8 caspase 8, apoptosis-related cysteine peptidase 841 Colon Cancer HT-29 - - - - Morusin, activate caspase-8 to elevate mitochondrial tBid and Bax to permeabilize the outer mitochondrial membrane, allowing eflux of cytochrome c and Smac/DIABLO into cytosol. 18485277
MMP-AC0202 CASP9 caspase 9, apoptosis-related cysteine peptidase 842 Colon Cancer HT-29 - - - - Morusin cause activation of caspase-9 at the 12h of treatmen. 18485277
MMP-AC0202 CHUK conserved helix-loop-helix ubiquitous kinase 1147 Colon Cancer HT-29 - - - - Morusin significantly decreased the phosphorylation i.e.,50% decrease for IKK-alpha at 48 h and total protein expression i.e., 60% at 12h. 18485277
MMP-AC0202 IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells 3551 Colon Cancer HT-29 - - - - Morusin significantly decreased the phosphorylation i.e.,30% decrease for IKK-Beta at 24 h and total protein expression i.e., 40% at 12. 18485277
MMP-AC0202 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 4790 Colon Cancer HT-29 - - - - Morusin dramatically decreased nuclear NF-kappaB p65 subunit at 12 h (more than 50% decrease) of treatment and reached the lowest level at 24-72 h (more then 90% decrease. 18485277