Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0212 |
AKT1 |
v-akt murine thymoma viral oncogene homolog 1 |
207 |
Breast Carcinoma |
MDA-MB-231 |
- |
- |
- |
- |
Results show that plumbagin targets the AKT signaling pathway. It can be firmly concluded that plumbagin induces autophagic cell death in MDA-MB-231 by suppression of the AKT pathway. |
17172425 |
MMP-AC0212 |
AKT1 |
v-akt murine thymoma viral oncogene homolog 1 |
207 |
Breast cancer |
MDA-MB-231 |
- |
- |
- |
- |
Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/d, where an nearly 70% reduction in tumor size was observed. Decreases of phospho-AKT was observed in the tumors of the plumbagin-treated mice in comparison with the tumors of vehicle-treated mice. |
Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/d, where an nearly 70% reduction in tumor size was observed. Decreases of phospho-AKT was observed in the tumors of the plumbagin-treated mice in comparison with the tumors of vehicle-treated mice. |
MMP-AC0212 |
BCL2 |
B-cell CLL/lymphoma 2 |
596 |
Breast Carcinoma |
MDA-MB-231 |
- |
- |
- |
- |
MDA-MB-231 cells treated with increasing concentrations of plumbagin for 24 and 72 h showed down-regulation of anti-apoptotic protein Bcl-2. |
18980240 |
MMP-AC0212 |
BCL2 |
B-cell CLL/lymphoma 2 |
596 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
Plumbagin-Induced Apoptosis of human breast cancer cells s mediated by inactivation of Bcl-. |
18980240 |
MMP-AC0212 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Epidermoid cervical carcinoma |
ME-180 |
- |
- |
- |
- |
There was a 2.5-fold increase in the caspase-3 activation on treatment with plumbagin. |
15264212 |
MMP-AC0212 |
MTOR |
mechanistic target of rapamycin (serine/threonine kinase) |
2475 |
Breast cancer |
MDA-MB-231 |
- |
- |
- |
- |
Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/d, where an nearly 70% reduction in tumor size was observed. The levels of phospho-mTOR were lower in the tumors from the plumbagin-treated group when compared with the tumors from vehicle-treated mice. |
17172425 |
MMP-AC0212 |
NFKB1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
4790 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
Induction of apoptosis in breast cancer cells by plumbagin could be mechanistically linked with the inactivation of NF-k. |
18980240 |
MMP-AC0212 |
NFKB1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
4790 |
Breast Carcinoma |
MDA-MB-231 |
- |
- |
- |
- |
Induction of apoptosis in breast cancer cells by plumbagin could be mechanistically linked with the inactivation of NF-k. |
18980240 |
MMP-AC0212 |
PIK3CA |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
5290 |
Breast Carcinoma |
MDA-MB-231 |
- |
- |
- |
- |
Plumbagin treatment of cells was found to cause a significant reduction in the expression of the regulatory subunit of PI3K (p85) protei. |
17172425 |
MMP-AC0212 |
PIK3CA |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
5290 |
Breast cancer |
MDA-MB-231 |
- |
- |
- |
- |
Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/d, where an nearly 70% reduction in tumor size was observed. Decreases of PI3K (p85) regulatory subunit was observed in the tumors of the plumbagin-treated mice in comparison with the tumors of vehicle-treated mice |
17172425 |