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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0218 : Sesamin

 
Compound Name  :
Sesamin		  
  Compound Class  : Lignans  
  Synonyms  : asarinin; epi-sesamin; episesamin; sesamin; sesamin, (1R (1alpha,3aalpha,4alpha,6aalpha))-isomer; sesamin, (1R (1alpha,3aalpha,4beta,6aalpha))-isomer

  
  Compound Extracted from  : Sesamin is extracted / reported from 5 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
72307		  
  Molecular Weight  : 354.4  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 0  
  Hydrogen Bond Acceptor count  : 6  
  Rotational Bond count  : 2  
  TPSA  : 55.4  
  LogP Value  :

 2.7

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
72307		  
  Drugbank ID  : -  
  Super Natural  : 000607807  
  CTD  : C054125  
  HIT  : C0579  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://pubchem.ncbi.nlm.nih.gov/compound/72307

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0218 MCF-7 Breast 3.4 µM - - - 15554262
MMP-AC0218 HCT-15 Colon 11.0 µM - - - 15554262
MMP-AC0218 HL-60 Haematopoietic and Lymphoid tissue 2,900 ng/ml - - - 8084211
MMP-AC0218 Molt-4 Haematopoietic and Lymphoid tissue 2,300 ng/ml - - - 8084211
MMP-AC0218 A549 Lung 4.4 µM - - - 15554262

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0218 AKT1 v-akt murine thymoma viral oncogene homolog 1 207 Breast adenocarcinoma MCF-7 - - - - Akt was activated (by phosphorylation) in MCF-7 cells within 1-h MøCM treatment, and Akt activities were potently inhibited by sesamin.20617373 20617373
MMP-AC0218 CCND1 cyclin D1 595 Breast adenocarcinoma MCF-7 - - - - Treatment with various concentrations of sesamin altered the expression of cyclin D1 protein. 17640297
MMP-AC0218 CCND1 cyclin D1 595 Breast Carcinoma T-47D - - - - Treatment with various concentrations of sesamin altered the expression of cyclin D1 protein. 17640297
MMP-AC0218 CCND1 cyclin D1 595 Lung adenocarcinom A549 - - - - Treatment with various concentrations of sesamin altered the expression of cyclin D1 protein. 17640297
MMP-AC0218 CCND1 cyclin D1 595 Melanoma UACC-62 - - - - Treatment with various concentrations of sesamin altered the expression of cyclin D1 protein. 17640297
MMP-AC0218 CCND1 cyclin D1 595 Osteosarcoma MG63 - - - - Treatment with various concentrations of sesamin altered the expression of cyclin D1 protein. 17640297
MMP-AC0218 HIF1A hypoxia inducible factor 1 3091 Breast adenocarcinoma MCF-7 - - - - HIF-1alpha was induced in the nuclear extract of MCF-7 cells after MøCM treatment, and the induction was attenuated by sesamin. 20617373
MMP-AC0218 IL6 interleukin 6 3569 Breast adenocarcinoma MCF-7 - - - - The levels of IL-6,was induced in MCF-7 cells when incubated with MfCM; additionally, sesamin was able to inhibit MfCM-induced IL-6 mRNA expression in a concentration-dependent manner. 20617373
MMP-AC0218 IL8 interleukin 8 3576 Breast adenocarcinoma MCF-7 - - - - The levels of IL-8 mRNA were all induced in MCF-7 cells when incubated with MfCM; additionally, sesamin was able to inhibit MfCM-induced IL-8, expression in a concentration-dependent manner. 20617373
MMP-AC0218 MAPK1 mitogen-activated protein kinase 1 5594 Breast adenocarcinoma MCF-7 - - - - p38MAPK was activated (by phosphorylation) in MCF-7 cells within 1-h MøCM treatment, and p38MAPK activities were potently inhibited by sesamin. 20617373
MMP-AC0218 MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 4318 Breast Carcinoma MDA-MB-231 - - - - inhibitory effect of sesamin on macrophage-induced MMP-9 expression was also observed with MDA-MB-231 cell. 20617373
MMP-AC0218 MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 4318 Breast adenocarcinoma MCF-7 - - - - MMP-9 mRNA expression was also induced in the MCF-7 cells after incubated with MfCM for 4 or 8 h, and sesamin was able to inhibit this MMP-9 mRNA induction. 20617373
MMP-AC0218 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 4790 Breast adenocarcinoma MCF-7 - - - - NF-kappaB was induced in the nuclear extract of MCF-7 cells after MøCM treatment, and the induction was attenuated by sesamin. 20617373
MMP-AC0218 PLCG1 phospholipase C, gamma 1 5335 Breast adenocarcinoma MCF-7 - - - - It is suggested that inhibition of PLC gamma 1 by this compound may be an important mechanism for an antiproliferative effect on the human cancer cells. 15554262
MMP-AC0218 PLCG1 phospholipase C, gamma 1 5335 Colon Cancer HCT-15 - - - - It is suggested that inhibition of PLC gamma 1 by this compound may be an important mechanism for an antiproliferative effect on the human cancer cells. 15554262
MMP-AC0218 PLCG1 phospholipase C, gamma 1 5335 Lung adenocarcinoma A549 - - - - It is suggested that inhibition of PLC gamma 1 by this compound may be an important mechanism for an antiproliferative effect on the human cancer cells. 15554262
MMP-AC0218 RB1 retinoblastoma 1 5925 Breast adenocarcinoma MCF-7 - - - - A hyperphosphorylated form of RB protein began to be converted into a hypophosphorylated form 3 h after treatment with sesamin. 17640297
MMP-AC0218 TNF tumor necrosis factor 7124 Breast adenocarcinoma MCF-7 - - - - The levels of TNF-alpha mRNA were all induced in MCF-7 cells when incubated with MfCM; additionally, sesamin was able to inhibit MfCM-induced TNF-alpha mRNA expression in a concentration-dependent manner. 20617373
MMP-AC0218 VEGFA vascular endothelial growth factor A 7422 Breast Carcinoma MDA-MB-231 - - - - inhibitory effect of sesamin on macrophage-induced VEGF expression was also observed with MDA-MB-231 cell. 20617373
MMP-AC0218 VEGFA vascular endothelial growth factor A 7422 Breast adenocarcinoma MCF-7 - - - - production of VEGF was significantly enhanced when MCF-7 cells were treated 24 h with MfCM compared with control treatment (454.5±81.2 vs. 207.9±50.6 pg/ml, P<0.05). 20617373