Tannic acid | MMP-AC0223

	Compound Name :	Tannic acid
	Compound Class :	Tannin
	Synonyms :	Gallotannic Acid; Gallotannin; Tannic Acid
	Compound Extracted from :	Tannic acid is extracted / reported from 9 Plant(s) of Melghat Flora as below MH032: Impatiens balsamina L.; MH236: Aerva lanata (L.) Juss. ex Schult.; MS005: Tamarix troupii Hole; MS050: Cassia occidentalis L.; MT009: Bombax ceiba L.; MT049: Terminalia bellirica (Gaertn.) Roxb.; MT050: Terminalia chebula Retz. ; MT088: Ficus racemosa L.; MT100: Acacia chundra (Rottler)Willd.;

	Molecular Formula :	C76H52O46
	Molecular Weight :	1701.2
	InChi Key :	LRBQNJMCXXYXIU-PPKXGCFTSA-N
	IUPAC :	[2,3-dihydroxy-5-[[(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]oxan-2-yl]methoxycarbonyl]phenyl] 3,4,5-trihydroxybenzoate
	InChi :	InChI=1S/C76H52O46/c77-32-1-22(2-33(78)53(32)92)67(103)113-47-16-27(11-42(87)58(47)97)66(102)112-21-52-63(119-72(108)28-12-43(88)59(98)48(17-28)114-68(104)23-3-34(79)54(93)35(80)4-23)64(120-73(109)29-13-44(89)60(99)49(18-29)115-69(105)24-5-36(81)55(94)37(82)6-24)65(121-74(110)30-14-45(90)61(100)50(19-30)116-70(106)25-7-38(83)56(95)39(84)8-25)76(118-52)122-75(111)31-15-46(91)62(101)51(20-31)117-71(107)26-9-40(85)57(96)41(86)10-26/h1-20,52,63-65,76-101H,21H2/t52-,63-,64+,65-,76+/m1/s1
	Hydrogen Bond Donor count :	25
	Hydrogen Bond Acceptor count :	46
	Rotational Bond count :	31
	TPSA :	778
	LogP Value :	6.2

	Lipinski Rule of Five :	No
	Ghose Filter :	No
	Veber Filter :	No
	Muegge Filter :	No

	PubChem CID :	16129778
	Drugbank ID :	DB09372
	Super Natural :	-
	CTD :	-
	HIT :	C0255
	NCI-60 GI50 data :	-

	Reference(s) :	https://pubchem.ncbi.nlm.nih.gov/compound/16129778

Compound_ID	Cell Lines	Cancer Type	IC50 Value	EC50 Value	ED50 Value	GI50 Value	References
MMP-AC0223	HOS-1	Bone	59.0ą0.19 ľg/ml	-	-	-	12127233

Compound_ID	Target	Gene_Name	Gene_ID	Cancer	Cell_lines	IC50 Value	EC50 Value	ED50 Value	GI50 Value	Remarks	References
MMP-AC0223	BAX	BCL2-associated X protein	581	T cell leukemia	Jurkat T	-	-	-	-	Tannic acid at 50 or 100ľg/ml also induced Bax expression by 3- to 7-fold, cause apoptosis. TA-induced apoptotic cell death is also time- and concentration-dependent. Therefore, accumulation of Bax by tannic acid before apoptosis is consistent with the fact that Bax acts as a cell death promoter.	11588135
MMP-AC0223	ODC1	ornithine decarboxylase 1	4953	-	-	-	-	-	-	Tannic acid pretreatments inhibit remarkably not only the induction of ODC activity produced by a single application of TPA but alsothe greater ODC responses elicited by each successive tumor promoter treatment.	2032222
MMP-AC0223	PSMD9	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	5715	T cell leukemia	Jurkat T	-	-	-	-	Treatment of tannic acid at 50 ľg/ml increased p27 levels by 2-fold at 4 h and by 3-fold at 12 and 24 h. And p27 acts as an inhibitor of the G1 to S phase transition .	11588135

MMP-AC0223 : Tannic acid