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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0020 : Hesperetin

 
Compound Name  :
Hesperetin		  
  Compound Class  : Flavonoid  
  Synonyms  : hesperetin; 520-33-2; Hesperitin; 3',5,7-Trihydroxy-4'-methoxyflavanone; Hesperin; YSO2; Cyanidanon 4'-methyl ether 1626; 5,7,3'-Trihydroxy-4'-methoxyflavanone (-)-hesperetin; NSC 57654;

  
  Compound Extracted from  : Hesperetin is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C16H14O6		  
  Molecular Weight  : 302.282  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 3  
  Hydrogen Bond Acceptor count  : 6  
  Rotational Bond count  : 2  
  TPSA  : 96.2  
  LogP Value  :

 2.4

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
72281		  
  Drugbank ID  : DB01094  
  Super Natural  : 000520263  
  CTD  : C013015  
  HIT  : -  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/22454667

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0020 CCRF-HSB-2 Haematopoietic and Lymphoid tissue >40 µM - - - 10380632
MMP-AC0020 A549 Lung >40 µM - - - 10380632
MMP-AC0020 B16 melanoma 4A5 Skin >40 µM - - - 10380632
MMP-AC0020 TGBC11TKB Stomach >40 µM - - - 10380632

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0020 BAX BCL2-associated X protein 581 Breast adenocarcinoma MCF-7 - - - - The expression of Bcl-2 associated x protein (Bax) as markers of apoptosis. Hesperetin increased that of Bax in a dose-dependent manner at 48 h. 17927510
MMP-AC0020 BAX BCL2-associated X protein 581 Gastric Cancer AGS - - - - Western blot results showed that expression level of Bax was increased in a dose-dependent manner. 22194772
MMP-AC0020 BCL2 B-cell CLL/lymphoma 2 596 Breast adenocarcinoma MCF-7 - - - - The expression of Bcl-2 as markers of apoptosis.Hesperetin decreased the expression of Bcl-2 in a dose-dependent manner at 48 . 17927510
MMP-AC0020 BCL2L1 BCL2-like 1 598 Breast adenocarcinoma MCF-7 - - - - It prevented the xenograft growth by down-regulating the expression of Bcl-x(L. 22209285
MMP-AC0020 BCL2L1 BCL2-like 1 598 Gastric Cancer AGS - - - - Western blot results showed that expression level of Bcl-xL was decreased in a dose-dependent manner. 22194772
MMP-AC0020 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Gastric Cancer AGS - - - - Flavonoids caused downregulation of procaspase-3 which consequently increased the activity of caspase-3. 22194772
MMP-AC0020 CCNB1 cyclin B1 891 Gastric Cancer AGS - - - - It reduces the protein level of cyclin B1 in a dose-dependent manner.Decrease of cyclin B1 expression might be a molecular mechanism through which flavonoids induce G2/M arrest. 22194772
MMP-AC0020 CCND1 cyclin D1 595 Breast adenocarcinoma MCF-7 - - - - It prevented the xenograft growth by down-regulating the expression of cyclin D. 22209285
MMP-AC0020 CCND1 cyclin D1 595 Breast adenocarcinoma MCF-7 - - - - The expression of cyclin D was inhibited after 48 h of 50 µM hesperetin.Hesperetin induced a decrease in cyclinD and CDK4, together with an increase in p21Cip1 and p27Kip1 associated with CDK4. 17927510
MMP-AC0020 CDC25C cell division cycle 25 homolog C (S. pombe) 995 Gastric Cancer AGS - - - - It reduces the protein level of cdc 25c in a dose-dependent manner.Decrease of cdc 25c expression might be a molecular mechanism through which flavonoids induce G2/M arrest. 22194772
MMP-AC0020 CDK1 cyclin-dependent kinase 1 983 Gastric Cancer AGS - - - - It reduces the protein level of cdc 2 in a dose-dependent manner.Decrease of cdc 2 expression might be a molecular mechanism through which flavonoids induce G2/M arrest. 22194772
MMP-AC0020 CDK2 cyclin-dependent kinase 2 1017 Breast adenocarcinoma MCF-7 - - - - Hesperetin treatment at high cncentration for 72 h resulted in a decrease in CDK2 and CDK4 together with cyclin D. A reduction in the expression of CDK2 and cyclin E was observed at the maximum concentration of 100 µM hesperetin for 72 h. 17927510
MMP-AC0020 CDK4 cyclin-dependent kinase 4 1019 Breast adenocarcinoma MCF-7 - - - - Hesperetin treatment resulted in a marked reduction in the expression of CDK4 in a dose-dependent manner after 48 and 72 h of treatment. 17927510
MMP-AC0020 CDK4 cyclin-dependent kinase 4 1019 Breast adenocarcinoma MCF-7 - - - - It prevented the xenograft growth by down-regulating the expression of CDK. 22209285
MMP-AC0020 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1026 Breast adenocarcinoma MCF-7 - - - - our data suggest for the first time that the regulation of CDK4 and p21Cip1 may participate in the anticancer activity pathway of hesperetin in MCF-7 cells. 17927510
MMP-AC0020 CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1027 Breast adenocarcinoma MCF-7 - - - - hesperetin down-regulates the cyclin-dependent kinases (CDKs) and cyclins and upregulates p21Cip1 and p27Kip1 in cells treated with hesperetin for 48 h and 72 h. 17927510
MMP-AC0020 CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2 1028 Breast adenocarcinoma MCF-7 - - - - It prevented the xenograft growth by down-regulating the expression of p57Kip. 22209285
MMP-AC0020 CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1588 Breast adenocarcinoma MCF-7 5 µM - - - HSP inhibited aromatase enzyme activity and suppressed proliferation of MCF-7aro cells in vivo. 22209285