Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0022 |
BAX |
BCL2-associated X protein |
581 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
Western blot results showed that expression level of Bax was increased in a dose-dependent manner. |
22194772 |
MMP-AC0022 |
BCL2L1 |
BCL2-like 1 |
598 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
Western blot results showed that expression level of Bcl-xL was decreased in a dose-dependent manner. |
22194772 |
MMP-AC0022 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
Flavonoids caused downregulation of procaspase-3 which consequently increased the activity of caspase-3. |
22194772 |
MMP-AC0022 |
CCNB1 |
cyclin B1 |
891 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
It reduces the protein level of cyclin B1 in a dose-dependent manner.Decrease of cyclin B1 expression might be a molecular mechanism through which flavonoids induce G2/M arrest. |
22194772 |
MMP-AC0022 |
CDC25C |
cell division cycle 25 homolog C (S. pombe) |
995 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
It reduces the protein level of cdc 25c in a dose-dependent manner.Decrease of cdc 25c expression might be a molecular mechanism through which flavonoids induce G2/M arrest. |
22194772 |
MMP-AC0022 |
CDK1 |
cyclin-dependent kinase 1 |
983 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
It reduces the protein level of cdc 2 in a dose-dependent manner.Decrease of cdc 2 expression might be a molecular mechanism through which flavonoids induce G2/M arrest. |
22194772 |
MMP-AC0022 |
COX-1 |
cytochrome c oxidase subunit I |
4512 |
Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus |
RAW264.7 |
164.6 µM |
- |
- |
- |
It inhibits cyclooxygenase 1 (Cox-1) activity and it is an anti-inflammatory mechanism. |
Phytochemistry Reviews 1: 369-377, 2002 |
MMP-AC0022 |
CYP19A1 |
cytochrome P450, family 19, subfamily A, polypeptide 1 |
1588 |
Breast adenocarcinoma |
MCF-7 |
2 µM |
- |
- |
- |
Naringenin inhibited aromatase activity with IC50 value of about 2µM. |
22209285 |
MMP-AC0022 |
CYP19A1 |
cytochrome P450, family 19, subfamily A, polypeptide 1 |
1588 |
Adrenocortical Carcinoma |
H295R |
85 µM |
- |
- |
- |
The first inhibitory effects on aromatase activity in vitro in H295R cells were observed at concentrations above 10 mM for naringenin and above 1 mM for chrysin and apigenin. |
15319488 |
MMP-AC0022 |
CYPIA1 |
cytochrome P450, family 1, subfamily A, polypeptide 1 |
1543 |
Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus |
RAW264.7 |
0.2 µM |
- |
- |
- |
Naringenin potently inhibited Cyp1A activity with an IC50 of 0.2 µM. Cyp1A, which is e.g. involved in the activation of carcinogens from grilled meat, as a model phase 1 enzyme, and measured the potential of beer constituents to inhibit its enzymatic activity. |
Phytochemistry Reviews 1: 369-377, 2002 |
MMP-AC0022 |
NOS2 |
nitric oxide synthase 2, inducible |
4843 |
Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus |
RAW264.7 |
12.9 µM |
- |
- |
- |
Nitric oxide (NO) synthase (iNOS) and consequently, enhance the generation of NO. Generally, NO is an important signaling molecule, long-term elevated levels of NO, however, have been linked to early steps in carcinogenesis.It cause inhibition of lipopolysaccharide (LPS)-mediated induction of inducible nitric oxide synthase , which is an anti-inflammatory mechanis. |
Phytochemistry Reviews 1: 369-377, 2002 |
MMP-AC0022 |
NQO1 |
NAD(P)H dehydrogenase, quinone 1 |
1728 |
Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus |
RAW264.7 |
>50 µM |
- |
- |
- |
It induces the QR activity.Induction of phases 2 enzymes contributes to chemopreventive activity. QR is not catalyzing a conjugation reaction, but it is induced co-ordinately with other phase 2 enzymes and contributes to detoxification by reduction of reactive quinones to less reactive hydroquinones. |
Phytochemistry Reviews 1: 369-377, 2002 |
MMP-AC0022 |
PARP1 |
poly (ADP-ribose) polymerase 1 |
142 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
During apoptosis, caspases induce PARP cleavage and inactivation and cleavage of PARP helps cellular disassembly and is a marker of cells undergoing apoptosis. |
22194772 |