Botanical Name Plant's Common Name Plant Family   

   MMP-AC0032 : Lycorine

 
Compound Name  :

Lycorine
 
  Compound Class  : Alkaloids  
  Synonyms  : lycorine; Galanthidine; Amarylline; Narcissine; 476-28-8; Licorine; (-)-Lycorine; Lycorine hydrochloride; UNII-I9Q105R5BU; EINECS 207-503-6; NSC401360; NSC683873; NSC 401360; 3,3a-Didehydrolycoran-1alpha,2beta-diol; CHEBI:6601; CHEMBL400092; I9Q105R5BU; GNF-PF-4974;

 
  Compound Extracted from  : Lycorine is extracted / reported from 3 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :

C16H17NO4
 
  Molecular Weight  : 287.315  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 2  
  Hydrogen Bond Acceptor count  : 5  
  Rotational Bond count  : 0  
  TPSA  : 62.2  
  LogP Value  :

0

 
 
Lipinski Rule of Five  :

Yes
 
  Ghose Filter  : No  
  Veber Filter  : Yes  
  Muegge Filter  :

Yes

 
 
PubChem CID  :

72378
 
  Drugbank ID  : -  
  Super Natural  : 029477836  
  CTD  : C015330  
  HIT  : C0335  
  NCI-60 GI50 data  :

476-28-8

 
 
Reference(s)  :

https://www.ncbi.nlm.nih.gov/pubmed/23376478


 

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0032 RAW264 Haematopoietic and Lymphoid tissue 2.1±0.4 µM - - - 21372424

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0032 NOS2 nitric oxide synthase 2, inducible 4843 Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus Raw264 1.2±0.4 µM - - - TNF-a suppressive alkaloids also inhibited NO production in RAW264 cell. 21372424
MMP-AC0032 TNF tumor necrosis factor 7124 Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus Raw264 2.1±0.4 µM - - - Lycorine suppressed the TNF-a production in LPS-stimulated RAW264 cells 21372424