Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0036 |
BCL2 |
B-cell CLL/lymphoma 2 |
596 |
Human Lung Carcinoma |
H69 |
- |
- |
- |
- |
The anti-apoptotic Bcl-2 genes were downregulated after the IC50 concentration of Solamargine treatment for 16 h. |
15527763 |
MMP-AC0036 |
BCL2 |
B-cell CLL/lymphoma 2 |
596 |
Large-cell carcinoma |
H-661 |
- |
- |
- |
- |
The anti-apoptotic Bcl-2 genes were downregulated after the IC50 concentration of Solamargine treatment for 16 h. |
15527763 |
MMP-AC0036 |
BCL2 |
B-cell CLL/lymphoma 2 |
596 |
Lung squamus carcinoma |
H520 |
- |
- |
- |
- |
The anti-apoptotic Bcl-2 genes were downregulated after the IC50 concentration of Solamargine treatment for 16 h. |
15527763 |
MMP-AC0036 |
BCL2 |
B-cell CLL/lymphoma 2 |
596 |
Papillary adenocarcinoma |
H-441 |
- |
- |
- |
- |
The anti-apoptotic Bcl-2 genes were downregulated after the IC50 concentration of Solamargine treatment for 16 h. |
15527763 |
MMP-AC0036 |
BCL2L1 |
BCL2-like 1 |
598 |
Human Lung Carcinoma |
Human Lung Carcinoma |
- |
- |
- |
- |
The anti-apoptotic Bcl-x(L) genes were downregulated after the IC50 concentration of Solamargine treatment for 16 h. |
15527763 |
MMP-AC0036 |
BCL2L1 |
BCL2-like 1 |
598 |
Large-cell carcinoma |
H-661 |
- |
- |
- |
- |
The anti-apoptotic Bcl-x(L) genes were downregulated after the IC50 concentration of Solamargine treatment for 16 h. |
15527763 |
MMP-AC0036 |
BCL2L1 |
BCL2-like 1 |
598 |
Lung squamus carcinoma |
H520 |
- |
- |
- |
- |
The anti-apoptotic Bcl-x(L) genes were downregulated after the IC50 concentration of Solamargine treatment for 16 h. |
h.gov/pubmed/15527763 |
MMP-AC0036 |
BCL2L1 |
BCL2-like 1 |
598 |
Papillary adenocarcinoma |
H-441 |
- |
- |
- |
- |
The anti-apoptotic Bcl-x(L) genes were downregulated after the IC50 concentration of Solamargine treatment for 16 h. |
15527763 |
MMP-AC0036 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Human Lung Carcinoma |
H69 |
- |
- |
- |
- |
Induction of apoptosis by Solamargine(SM) in lung cancers was accompanied by significant increase in caspase-3 activity . At the late phase of apoptosis, the activation of caspase-3 will cleave DNA into oligonucleosomal fragments (180-200 bp). |
15527763 |
MMP-AC0036 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Large-cell carcinoma |
H-661 |
- |
- |
- |
- |
Induction of apoptosis by Solamargine(SM) in lung cancers was accompanied by significant increase in caspase-3 activity . At the late phase of apoptosis, the activation of caspase-3 will cleave DNA into oligonucleosomal fragments (180-200 bp). |
15527763 |
MMP-AC0036 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Lung squamus carcinoma |
H520 |
- |
- |
- |
- |
Induction of apoptosis by Solamargine(SM) in lung cancers was accompanied by significant increase in caspase-3 activity . At the late phase of apoptosis, the activation of caspase-3 will cleave DNA into oligonucleosomal fragments (180-200 bp). |
15527763 |
MMP-AC0036 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Papillary adenocarcinoma |
H-441 |
- |
- |
- |
- |
Induction of apoptosis by Solamargine(SM) in lung cancers was accompanied by significant increase in caspase-3 activity . At the late phase of apoptosis, the activation of caspase-3 will cleave DNA into oligonucleosomal fragments (180-200 bp). |
15527763 |
MMP-AC0036 |
CYCS |
cytochrome c |
54205 |
Human Lung Carcinoma |
H69 |
- |
- |
- |
- |
Solamargine caused the release of cytochrome c from mitochondria. |
15527763 |
MMP-AC0036 |
CYCS |
cytochrome c |
54205 |
Large-cell carcinoma |
H-661 |
- |
- |
- |
- |
Solamargine caused the release of cytochrome c from mitochondria. |
15527763 |
MMP-AC0036 |
CYCS |
cytochrome c |
54205 |
Lung squamus carcinoma |
H520 |
- |
- |
- |
- |
Solamargine caused the release of cytochrome c from mitochondria. |
15527763 |
MMP-AC0036 |
CYCS |
cytochrome c |
54205 |
Papillary adenocarcinoma |
H-441 |
- |
- |
- |
- |
Solamargine caused the release of cytochrome c from mitochondria. |
15527763 |
MMP-AC0036 |
ERBB2 |
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 |
2064 |
Lung adenocarcinoma |
A549 |
- |
- |
- |
- |
The ratios of HER2 to b-actin gene expressions revealed that cells treated with SM exhibited a level of significance of HER2 expression lower than the untreated control. |
17639997 |
MMP-AC0036 |
FADD |
Fas (TNFRSF6)-associated via death domain |
8772 |
Human Lung Carcinoma |
H69 |
- |
- |
- |
- |
The apoptotic FADD genes was upregulated after the IC50 concentration of Solamargine treatment for 16 h. |
15527763 |
MMP-AC0036 |
Fas |
TNF receptor superfamily, member 6 |
355 |
Lung adenocarcinoma |
A549 |
- |
- |
- |
- |
Adding Solamargine up-regulated the gene expression of Fas in A549 cells according to RT-PCR. |
17639997 |
MMP-AC0036 |
LTA |
lymphotoxin alpha (TNF superfamily, member 1) |
4049 |
Human Lung Carcinoma |
H69 |
- |
- |
- |
- |
Solamargine increased the expression of TNFRs and consequently improved the susceptibility of lung cancer cells to TNF beta |
15527763 |
MMP-AC0036 |
TNF |
tumor necrosis factor |
7124 |
Human Lung Carcinoma |
H69 |
- |
- |
- |
- |
Solamargine increased the expression of TNFRs and consequently improved the susceptibility of lung cancer cells to TNF-alpha |
15527763 |
MMP-AC0036 |
TNFRSF1A |
tumor necrosis factor receptor superfamily, member 1A |
7132 |
Hepatoma |
Hep-3B |
- |
- |
- |
- |
Results revealed that solamargine could elevate the gene and protein expressions of TNFR-I of Hep3B cells. |
11108802 |
MMP-AC0036 |
TOP2A |
topoisomerase (DNA) II alpha 170kDa |
7153 |
Lung adenocarcinoma |
A549 |
- |
- |
- |
- |
Solamargine down-regulated the gene expression of TOP2A in A549 and H441 cells, as determined by comparison with the control. |
17639997 |
MMP-AC0036 |
TRADD |
TNFRSF1A-associated via death domain |
8717 |
Lung squamus carcinoma |
H520 |
- |
- |
- |
- |
The apoptotic TRADD genes was upregulated after the IC50 concentration of Solamargine treatment for 16 h. |
15527763 |