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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0040 : Diosgenin

 
Compound Name  :
Diosgenin		  
  Compound Class  : Saponin  
  Synonyms  : DIOSGENIN; 512-04-9; Nitogenin; UNII-K49P2K8WLX; K49P2K8WLX; CHEBI:4629; (25R)-spirost-5-en-3beta-diol; Spirost-5-en-3-ol, (3b,25R)-; (20R,25R)-Spirost-5-en-3beta-ol; CCRIS 6803; 22alpha-Spirost-5-en-3beta-ol; (25R)-Spirost-5-en-3beta-ol; SP 37; (3beta,25R)-spirost-5-en-3-ol; EINECS 208-134-3; NSC 33396; BRN 0094582; 3beta-Hydroxy-5-spirostene; (25R)-5-Spirosten-3beta-ol; nitrogen in;

  
  Compound Extracted from  : Diosgenin is extracted / reported from 8 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C27H42O3		  
  Molecular Weight  : 414.63  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 1  
  Hydrogen Bond Acceptor count  : 3  
  Rotational Bond count  : 0  
  TPSA  : 38.7  
  LogP Value  :

 5.7

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : No  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
99474		  
  Drugbank ID  : -  
  Super Natural  : 000512049  
  CTD  : D004144  
  HIT  : C0330  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/28954389

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0040 HCT-116 Colon ~35 µM - - - 17555873

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0040 AKT1 v-akt murine thymoma viral oncogene homolog 1 207 Breast Adenocarcinoma AU565 - - - - Diosgenin inhibited the phosphorylation of Akt 18022396
MMP-AC0040 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Epidermoid carcinoma of larynx Hep-2 - - - - At 24 h,caspase activities were enhanced significantly (1.6-fold for caspase-3 versus controls, p<0.01) 15225412
MMP-AC0040 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Tumors M-4-BEU - - - - caspase-3 activity was more markedly induced at the same time (3.4- and 2.2-fold respectively versus controls, p<0.01) 15225412
MMP-AC0040 CASP9 caspase 9, apoptosis-related cysteine peptidase 842 Epidermoid carcinoma of larynx Hep-2 - - - - At 24 h,caspase activities were enhanced significantly (1.2-fold for caspase-9 versus controls, p<0.01) 15225412
MMP-AC0040 CASP9 caspase 9, apoptosis-related cysteine peptidase 842 Tumors M-4-BEU - - - - caspase-9 activity was moderately induced at 12 and 24 h [1.3-(p<0.01) and 1.2-fold (p<0.05) at 12 and 24 h respectively versus controls] 15225412
MMP-AC0040 Fas TNF receptor superfamily, member 6 355 Breast Adenocarcinoma AU565 - - - - Diosgenin, a plant-derived steroid, was found to be effective in suppressing FAS expression in HER2-overexpressing breast cancer cells. Diosgenin preferentially inhibited proliferation and induced apoptosis in HER2-overexpressing cancer cells. 18022396
MMP-AC0040 MAPK8 mitogen-activated protein kinase 8 5599 Breast Adenocarcinoma AU565 - - - - Diosgenin enhanced phosphorylation of JNK. 18022396
MMP-AC0040 MTOR mechanistic target of rapamycin (serine/threonine kinase) 2475 Breast Adenocarcinoma AU565 - - - - Diosgenin enhanced phosphorylation of JNK. 18022396
MMP-AC0040 PARP1 poly (ADP-ribose) polymerase 1 142 Epidermoid carcinoma of larynx Hep-2 - - - - Partial PARP cleavage was observed by treating cells with diosgenin. 15225412
MMP-AC0040 PARP1 poly (ADP-ribose) polymerase 1 142 Tumors M-4-BEU - - - - Partial PARP cleavage was observed by treating cells with diosgenin. 15225412