Botanical Name Plant's Common Name Plant Family   

   MMP-AC0058 : Cucurbitacin B

 
Compound Name  :

Cucurbitacin B
 
  Compound Class  : Terpenoids  
  Synonyms  : Cucurbitacin B; 6199-67-3; Cucurbitacin-B; UNII-0115W5MABF; Amarine;

 
  Compound Extracted from  : Cucurbitacin B is extracted / reported from 4 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :

C32H46O8
 
  Molecular Weight  : 558.7  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 3  
  Hydrogen Bond Acceptor count  : 8  
  Rotational Bond count  : 6  
  TPSA  : 138  
  LogP Value  :

2.6

 
 
Lipinski Rule of Five  :

No
 
  Ghose Filter  : No  
  Veber Filter  : Yes  
  Muegge Filter  :

Yes

 
 
PubChem CID  :

5281316
 
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C041246  
  HIT  : C0518  
  NCI-60 GI50 data  :

6199-67-3

 
 
Reference(s)  :

https://www.ncbi.nlm.nih.gov/pubmed/24316209


 

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0058 BT-474 Breast - - 0.000000136 M - 18627377
MMP-AC0058 MCF-7 Breast - - 0.0000000363 M - 18627377
MMP-AC0058 MDA-MB-231 Breast 18627377
MMP-AC0058 MDA-MB-453 Breast - - 0.0000000303 M - 18627377
MMP-AC0058 ZR-75-1 Breast - - 0.000000032 M - 18627377
MMP-AC0058 T-47D Breast - - 0.000000118 M - 18627377
MMP-AC0058 U-937 Haematopoietic and Lymphoid tissue 9.2 nM (72h) - - - 20460809
MMP-AC0058 U-937 Haematopoietic and Lymphoid tissue 25 nM (24h) - - - 20460809

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0058 BCL2 B-cell CLL/lymphoma 2 596 Epidermoid carcinoma of larynx Hep-2 - - - - Measuring the modulation of regulators in the cell cycle, apoptosis and signal transductions by Western blot analysis showed that the effect of cucurbitacin B was due to suppression of the expression of Bcl-2. 18309509
MMP-AC0058 CCNB1 cyclin B1 891 Epidermoid carcinoma of larynx Hep-2 - - - - Measuring the modulation of regulators in the cell cycle, apoptosis and signal transductions by Western blot analysis showed that the effect of cucurbitacin B was due to suppression of the expression of cyclin B1. 18309509
MMP-AC0058 BCL2L1 BCL2-like 1 598 Pancreatic Cancer PANC-1 - - - - The drug also decreased the protein level of the antiapoptotic Bcl-XL protein over 24 h. 19605406
MMP-AC0058 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Pancreatic Cancer PANC-1 - - - - The drug increased the proapoptotic caspase-3 over 24 h. 19605406
MMP-AC0058 CASP9 caspase 9, apoptosis-related cysteine peptidase 842 Pancreatic Cancer PANC-1 - - - - The drug increased the proapoptotic caspase-9 enzyme level associated with PARP cleavage over 24 h. 19605406
MMP-AC0058 CCNB1 cyclin B1 891 Pancreatic Cancer PANC-1 - - - - The cell cycle regulators cyclin B1 decreased after 24 h exposure to cucurbitacin . 19605406