Ginkgetin | MMP-AC0060

	Compound Name :	Ginkgetin
	Compound Class :	Flavonoid
	Synonyms :	Ginkgetin; 481-46-9; Amentoflavone 7,4'-dimethyl ether; 7,4'-Dimethylamentoflavone; CHEBI:5353;
	Compound Extracted from :	Ginkgetin is extracted / reported from 1 Plant(s) of Melghat Flora as below MH309: Cyperus compressus L.;

	Molecular Formula :	C32H22O10
	Molecular Weight :	566.5
	InChi Key :	AIFCFBUSLAEIBR-UHFFFAOYSA-N
	IUPAC :	5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)chromen-4-one
	InChi :	InChI=1S/C32H22O10/c1-39-18-10-20(34)30-23(37)13-27(41-28(30)11-18)16-5-8-25(40-2)19(9-16)29-21(35)12-22(36)31-24(38)14-26(42-32(29)31)15-3-6-17(33)7-4-15/h3-14,33-36H,1-2H3
	Hydrogen Bond Donor count :	4
	Hydrogen Bond Acceptor count :	10
	Rotational Bond count :	5
	TPSA :	152
	LogP Value :	5.7

	Lipinski Rule of Five :	No
	Ghose Filter :	No
	Veber Filter :	No
	Muegge Filter :	No

	PubChem CID :	5271805
	Drugbank ID :	-
	Super Natural :	-
	CTD :	C077458
	HIT :	-
	NCI-60 GI50 data :	-

	Reference(s) :	https://www.ncbi.nlm.nih.gov/pubmed/25968939

Compound_ID	Cell Lines	Cancer Type	IC50 Value	EC50 Value	ED50 Value	GI50 Value	References
MMP-AC0060	OVCAR-3	Ovary	1.8 痢/ml	-	-	-	9134745

Compound_ID	Target	Gene_Name	Gene_ID	Cancer	Cell_lines	IC50 Value	EC50 Value	ED50 Value	GI50 Value	Remarks	References
MMP-AC0060	CASP3	caspase 3, apoptosis-related cysteine peptidase	836	Ovarian adenocarcinoma	OVCAR-3	-	-	-	-	A decrease in pro-caspase-3 was clearly observed 12 h after the addition of ginkgetin (3 痢/ml), indicating the activation of this protease.such activation could still be detected 30 h post drug treatment. Here, the apoptosis induced by a high concentration of ginkgetin is mediated mainly by caspase(s) activated by H2O2 generated possibly through autooxidation of this biflavone.	10935537

MMP-AC0060 : Ginkgetin