Botanical Name Plant's Common Name Plant Family   

   MMP-AC0069 : Corosolic acid

 
Compound Name  :

Corosolic acid
 
  Compound Class  : Terpenoids  
  Synonyms  : Corosolic acid; 4547-24-4; Glucosol; Colosic acid; Corsolic acid;

 
  Compound Extracted from  : Corosolic acid is extracted / reported from 3 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :

C30H48O4
 
  Molecular Weight  : 472.7  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 3  
  Hydrogen Bond Acceptor count  : 4  
  Rotational Bond count  : 1  
  TPSA  : 77.8  
  LogP Value  :

6.4

 
 
Lipinski Rule of Five  :

No
 
  Ghose Filter  : No  
  Veber Filter  : Yes  
  Muegge Filter  :

No

 
 
PubChem CID  :

6918774
 
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C113861  
  HIT  : -  
  NCI-60 GI50 data  :

-

 
 
Reference(s)  :

https://www.ncbi.nlm.nih.gov/pubmed/24566423


 

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0069 MCF-7 Breast - - - 309±28 µM 16448187

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0069 BAX BCL2-associated X protein 581 Cervix Adenocarcinoma HeLa - - - - HeLa cells resulted in an increased level of Bax expression in a time dependent manner. Results suggest that CRA-induced apoptosis in HeLa cells via alteration of the Bax/Bcl-2 ratio. 19457606
MMP-AC0069 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Cervix Adenocarcinoma HeLa - - - - Caspase-3 activity increased 9.6-fold after 12 h and 14.9-fold after 24 h treatment. 19457606
MMP-AC0069 CASP8 caspase 8, apoptosis-related cysteine peptidase 841 Cervix Adenocarcinoma HeLa - - - - The activities of caspase-8 increased 1.6-fold after 12 h, 2.3-fold after 24 h treatment, respectivel. 19457606
MMP-AC0069 CASP9 caspase 9, apoptosis-related cysteine peptidase 842 Cervix Adenocarcinoma HeLa - - - - The activities of caspase-9 increased 2.3-fold after 12 h,3.4-fold after 24 h treatment, respectivel. 19457606