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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0076 : Liquiritigenin

 
Compound Name  :
Liquiritigenin		  
  Compound Class  : Flavonoid  
  Synonyms  : Liquiritigenin; 578-86-9; 4',7-Dihydroxyflavanone; (S)-7-Hydroxy-2-(4-hydroxyphenyl)chroman-4-one; (2S)-liquiritigenin;

  
  Compound Extracted from  : Liquiritigenin is extracted / reported from 3 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C15H12O4		  
  Molecular Weight  : 256.25  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 2  
  Hydrogen Bond Acceptor count  : 4  
  Rotational Bond count  : 1  
  TPSA  : 66.8  
  LogP Value  :

 2.2

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
114829		  
  Drugbank ID  : -  
  Super Natural  : 000554358  
  CTD  : C083152  
  HIT  : -  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/29908794

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0076 HL-60 Hematopoietic and Lymphoid tissue 290 ng/ml - - - 8084211
MMP-AC0076 Molt-4 Hematopoietic and Lymphoid tissue 3,200 ng/ml - - - 8084211
MMP-AC0076 AGS Stomach 339.3 µM - - - 21216524
MMP-AC0076 MKN-28 Stomach 314.7 µM - - - 21216524
MMP-AC0076 MKN-45 Stomach 376.7 µM - - - 21216524
MMP-AC0076 SGC-7901 Stomach 358.0 µM - - - 21216524

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0076 BCL2 B-cell CLL/lymphoma 2 596 Hepatocellular carcinoma SMMC-7721 - - - - The level of Bcl-2 protein significantly decreased in a time-dependent manner after liquiritigenin treatment, which gradually disappeared at 72 h. And the ratio of Bcl-2/b-actin band densities was observed in a time-dependent decrease significantly. 19150383
MMP-AC0076 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Hepatocellular carcinoma SMMC-7721 - - - - Caspase-3 plays a central role in mediating various apoptotic responses. In this study, caspase-3 protease activity significantly increased in a time-dependent manner after liquiritigenin treatment. 0.4 mM liquiritigenin strongly induced activation of caspae-3 protease as early as 24 h, and the maximum activity at 72 h was 773.94 ± 31.04%, which was about 7-fold increase compared with control. 19150383
MMP-AC0076 GPX1 glutathione peroxidase 1 2876 Hepatocellular carcinoma SMMC-7721 - - - - The data show that activities of Glutathione Peroxidase decreased in time-dependent manner after cells treated with 0.4 mM liquiritigenin. And the GSH-PX activities significantly decreased at 24, 48 and 72 h (p< 0.05), which decreased to 15.4 ± 4.7 U (72 h) from 37.7 ± 2.9 U (0 h. 19150383
MMP-AC0076 SOD1 superoxide dismutase 1 6647 Hepatocellular carcinoma SMMC-7721 - - - - The data show that activities of Superoxide Dismutase(SOD) decreased in a time-dependent manner after cells treated with 0.4 mM liquiritigenin. 19150383
MMP-AC0076 TP53 tumor protein p53 7157 Hepatocellular carcinoma SMMC-7721 - - - - 0.4 mM liquiritigenin induced a significant increase in the expression of p53. The level of p53 increased significantly when SMMC7721cells were treated with 0.4 mM liquiritigenin for 12 h and remained elevated until 72 h. Densitometric analysis showed the increases in the ratio of p53/b-actin band densities reached statistical significance at 48 h(2.0-fold, p < 0.05) and 72 h (2.4-fold, p < 0.01). 19150383
MMP-AC0076 VEGFA vascular endothelial growth factor A 7422 Cervical cancer HeLa - - - - Liquiritigenin effectively inhibited the growth of tumors xenografted in nude mice from human cervical cancer cell line HeLa cells. From the analysis, it was concluded that liquiritigenin could suppress the proliferation of tumor cells by inhibiting VEGF expression to prevent the angiogenesis of tumors. 22692244