HOME
BROWSE
FLORA
CONTACT
Botanical Name Plant's Common Name Plant Family   

   MMP-AC0097 : Costunolide

 
Compound Name  :
Costunolide		  
  Compound Class  : Terpenoids  
  Synonyms  : Costunolide; 553-21-9; (+)-costunolide; Costunlide; Costundide;

  
  Compound Extracted from  : Costunolide is extracted / reported from 2 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C15H20O2		  
  Molecular Weight  : 232.32  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 0  
  Hydrogen Bond Acceptor count  : 2  
  Rotational Bond count  : 0  
  TPSA  : 26.3  
  LogP Value  :

 2.1

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
5281437		  
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C002602  
  HIT  : C0359  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/22985027

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0097 Colon 26 Colon - - 17.2±1.4 µM - 11534769
MMP-AC0097 HL-60 Haematopoietic and Lymphoid tissue 114.7±0.05 µM - 9.5±0.8 µM - 11534769
MMP-AC0097 3LL Lung - - 19.3±1.9 µM - 11534769
MMP-AC0097 J82 Urinary Bladder - - 16.4±2.5 µM - 11534769
MMP-AC0097 T24 Urinary Bladder - - 23.9±3.5 µM - 11534769

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0097 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Breast Carcinoma MDA-MB-231 - - - - Costunolide suppresses cell growth in MDA-MB-231 breast cancer cells through extrinsic-apoptotic pathway related with activation of Caspase-3. 22147197
MMP-AC0097 ASP8 caspase 8, apoptosis-related cysteine peptidase 841 Breast Carcinoma MDA-MB-231 - - - - costunolide suppresses cell growth in MDA-MB-231 breast cancer cells through extrinsic-apoptotic pathway related with activation of caspase-8. 22147197
MMP-AC0097 CCNB1 cyclin B1 891 Breast Carcinoma MDA-MB-231 - - - - Costunolide treatment resulted in a decrease in the levels of central protein for G2/M transition such as Cdc2 and cyclin B. 22147197
MMP-AC0097 CDK1 cyclin-dependent kinase 1 983 Breast Carcinoma MDA-MB-231 - - - - Costunolide treatment resulted in a decrease in the levels of central protein for G2/M transition such as Cdc2. 22147197
MMP-AC0097 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1026 Breast Carcinoma MDA-MB-231 - - - - Costunolide-induced G2/M cell cycle arrest is associated with upregulation of p21WAF1 in MDA-MB-231 cells through a p53-independent pathway. 22147197
MMP-AC0097 Fas TNF receptor superfamily, member 6 355 Breast Carcinoma MDA-MB-231 - - - - costunolide suppresses cell growth in MDA-MB-231 breast cancer cells through extrinsic-apoptotic pathway related with activation of Fas-death receptor. 22147197
MMP-AC0097 PARP1 poly (ADP-ribose) polymerase 1 142 Breast Carcinoma MDA-MB-231 - - - - we found that the cleavage of PARP was inhibited after 24-h incubation while costunolide alone still shows the degradation of PAR. 22147197