Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0103 |
BAX |
BCL2-associated X protein |
581 |
Human osteosarcoma |
U2os |
- |
- |
- |
- |
Our immunocytochemistry findings for Bax and Bcl2 revealed that b-ionone increased the expression of Bax but decreased the expression of Bcl2. The Bax protein was relatively concentrated in the mitochondria in U2os cells after 200 lM b-ionone treatment for 48. |
19757179 |
MMP-AC0103 |
BCL2 |
B-cell CLL/lymphoma 2 |
596 |
Human osteosarcoma |
U2os |
- |
- |
- |
- |
Our immunocytochemistry findings for Bax and Bcl2 revealed that b-ionone increased the expression of Bax but decreased the expression of Bcl. |
19757179 |
MMP-AC0103 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Human osteosarcoma |
U2os |
- |
- |
- |
- |
The Caspase-3 cellular activity showed a significant increase in cells treated with 200 lM b-ionone for 48 h compared with cells treated with b-ionone for 12 or 24 h. Because the activity of Caspase-3 was significantly increased in U2os cells treated with 200 lM b-ionone for 48 h, this treatment was considered to represent the optimal induction condition of apoptosis. |
19757179 |
MMP-AC0103 |
CCND1 |
cyclin D1 |
595 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
A significant, concentration-dependent decrease in expression of the early G1 phase cyclin D1 was observed in MCF-7 cells treated with beta-ionone. |
15450939 |
MMP-AC0103 |
CCNE1 |
cyclin E1 |
898 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
Protein levels of cyclin E in cells treated with 400 or 500 mM b-ionone. |
15450939 |
MMP-AC0103 |
CDK2 |
cyclin-dependent kinase 2 |
1017 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
Protein levels of CDK 2, decreased significantly in cells treated with 400 or 500 mM b-ionone. |
15450939 |
MMP-AC0103 |
CycA |
Cyclin A |
39340 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
Expression of cyclin A, the S phase CDK 2 activator, decreased significantly following treatment of cells with beta-ionone. |
15450939 |
MMP-AC0103 |
CYCS |
cytochrome c |
54205 |
Human osteosarcoma |
U2os |
- |
- |
- |
- |
Cytochrome c is released from the mitochondria in response to b-ionone via Bcl2 family-regulated mechanisms.The release of cytochrome c is a characteristic of cellular apoptosis. In U2os cells treated with b-ionone for 48 h, the cytochrome c protein was relatively diffusely expressed in the cytosol. |
19757179 |
MMP-AC0103 |
TP53 |
tumor protein p53 |
7157 |
Human osteosarcoma |
U2os |
- |
- |
- |
- |
The immunocytochemical results of p53 showed that the expression of p53 was increased by b-ionone in dose-dependent manner over 48 h. Besides, p53 protein was detected in U2os cells that incubated with 200 lM b-ionone for 12, 24,36, and 48 h, the expression of p53 was increased by b-ionone in a time-dependent manner. |
19757179 |