Botanical Name Plant's Common Name Plant Family   

   MMP-AC0106 : Morin

 
Compound Name  :

Morin
 
  Compound Class  : Flavonoid  
  Synonyms  : morin; 480-16-0; Aurantica; Calico Yellow; Al-Morin;

 
  Compound Extracted from  : Morin is extracted / reported from 3 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :

C15H10O7
 
  Molecular Weight  : 302.23  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 5  
  Hydrogen Bond Acceptor count  : 7  
  Rotational Bond count  : 1  
  TPSA  :  
  LogP Value  :

1.5

 
 
Lipinski Rule of Five  :

Yes
 
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

Yes

 
 
PubChem CID  :

5281670
 
  Drugbank ID  : -  
  Super Natural  : 000480160  
  CTD  : C008548  
  HIT  : C0311  
  NCI-60 GI50 data  :

480-16-0

 
 
Reference(s)  :

https://www.ncbi.nlm.nih.gov/pubmed/28689916


 

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0106 L929 Connective tissue - 120±8 µM - - 12628514
MMP-AC0106 L929 Connective tissue - 115±10 µM - - 12628514
MMP-AC0106 HL-60 Haematopoietic and Lymphoid tissue 2,400 ng/ml - - - 8084211
MMP-AC0106 Molt-4 Haematopoietic and Lymphoid tissue 3,500 ng/ml - - - 8084211

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0106 COX-2 cytochrome c oxidase subunit II 4513 Hepatocellular Carcinoma - - - - - During this cancer, inflammation of the liver cause due to up-regulation of NF-kappaB-p65 and COX-2.Oral supplementation of morin (500 ppm in diet) to DEN-induced hepatocellular carcinoma down-regulated the expression of COX-2, thereby preventing inflammation and angiogenesis mediated hepatocellular carcinogenesis. 19539802
MMP-AC0106 MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 4313 Hepatocellular Carcinoma - - - - - Matrix metalloproteinase MMP-2 has role in ngiogenesis in DEN induced hepatocellular carcinoma. MMP-2 level was found to be increased in DEN-induced animals when compared to control. MMP-2 levels were down-regulated in morin post-treated animals when compared to DEN-induced animals favouring prevention of angiogenesis. 19539802
MMP-AC0106 MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 4318 Hepatocellular Carcinoma - - - - - Matrix metalloproteinase MMP-9 has role in ngiogenesis in DEN induced hepatocellular carcinoma. MMP-9 level was found to be increased in DEN-induced animals when compared to control. MMP-9 level was down-regulated in morin post-treated animals when compared to DEN-induced animals favouring prevention of angiogenesis. 19539802
MMP-AC0106 RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 5970 Hepatocellular Carcinoma - - - - - During this cancer, inflammation of the liver cause due to up-regulation of NF-kappaB-p65 and COX-2. Oral supplementation of morin (500 ppm in diet) to DEN-induced hepatocellular carcinoma down-regulated the expression of NF-kappaB-p65, thereby preventing inflammation and angiogenesis mediated hepatocellular carcinogenesis. 19539802
MMP-AC0106 TNF tumor necrosis factor 7124 TNF sensitive murine fibroblast cells L929 - - 115±10 µM - The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. 9287415
MMP-AC0106 TNF tumor necrosis factor 7124 TNF sensitive murine fibroblast cells L929 - - 120±8 µM - The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. 9287415