Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0106 |
COX-2 |
cytochrome c oxidase subunit II |
4513 |
Hepatocellular Carcinoma |
- |
- |
- |
- |
- |
During this cancer, inflammation of the liver cause due to up-regulation of NF-kappaB-p65 and COX-2.Oral supplementation of morin (500 ppm in diet) to DEN-induced hepatocellular carcinoma down-regulated the expression of COX-2, thereby preventing inflammation and angiogenesis mediated hepatocellular carcinogenesis. |
19539802 |
MMP-AC0106 |
MMP2 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) |
4313 |
Hepatocellular Carcinoma |
- |
- |
- |
- |
- |
Matrix metalloproteinase MMP-2 has role in ngiogenesis in DEN induced hepatocellular carcinoma. MMP-2 level was found to be increased in DEN-induced animals when compared to control. MMP-2 levels were down-regulated in morin post-treated animals when compared to DEN-induced animals favouring prevention of angiogenesis. |
19539802 |
MMP-AC0106 |
MMP9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) |
4318 |
Hepatocellular Carcinoma |
- |
- |
- |
- |
- |
Matrix metalloproteinase MMP-9 has role in ngiogenesis in DEN induced hepatocellular carcinoma. MMP-9 level was found to be increased in DEN-induced animals when compared to control. MMP-9 level was down-regulated in morin post-treated animals when compared to DEN-induced animals favouring prevention of angiogenesis. |
19539802 |
MMP-AC0106 |
RELA |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
5970 |
Hepatocellular Carcinoma |
- |
- |
- |
- |
- |
During this cancer, inflammation of the liver cause due to up-regulation of NF-kappaB-p65 and COX-2. Oral supplementation of morin (500 ppm in diet) to DEN-induced hepatocellular carcinoma down-regulated the expression of NF-kappaB-p65, thereby preventing inflammation and angiogenesis mediated hepatocellular carcinogenesis. |
19539802 |
MMP-AC0106 |
TNF |
tumor necrosis factor |
7124 |
TNF sensitive murine fibroblast cells |
L929 |
- |
- |
115±10 µM |
- |
The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. |
9287415 |
MMP-AC0106 |
TNF |
tumor necrosis factor |
7124 |
TNF sensitive murine fibroblast cells |
L929 |
- |
- |
120±8 µM |
- |
The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. |
9287415 |