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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0114 : Nobiletin

 
Compound Name  :
Nobiletin		  
  Compound Class  : Flavonoid  
  Synonyms  : Nobiletin; 478-01-3; Hexamethoxyflavone; 3',4',5,6,7,8-Hexamethoxyflavone; 5,6,7,8,3',4'-Hexamethoxyflavone;

  
  Compound Extracted from  : Nobiletin is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C21H22O8		  
  Molecular Weight  : 402.4  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 0  
  Hydrogen Bond Acceptor count  : 8  
  Rotational Bond count  : 7  
  TPSA  : 81.7  
  LogP Value  :

 3

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
72344		  
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C008661  
  HIT  : C0582  
  NCI-60 GI50 data  :

 478-01-3

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/24964900

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0114 MCF-7 Breast 2.9 然 - - - 12355447
MMP-AC0114 MDA-MB-435 ER- Breast 1.2 然 - - - 12355447
MMP-AC0114 HT-29 Colon 4.7 然 - - - 12355447
MMP-AC0114 CCRF-HSB-2 Haematopoietic and Lymphoid tissue 13.0 然 - - - 10380632
MMP-AC0114 A549 Lung 22.0 然 - - - 10380632
MMP-AC0114 DMS-114 Lung 3.5 然 - - - 12355447
MMP-AC0114 DU-145 Prostate 1.0 然 - - - 12355447
MMP-AC0114 B16 melanoma 4A5 Skin 18.0 然 - - - 10380632
MMP-AC0114 SK-MEL-5 Skin 0.50 然 - - - 12355447
MMP-AC0114 TGBC11TKB Stomach 8.3 然 - - - 10380632

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0114 ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 5243 Colorectal Adenocarcinoma CaCo-2 - - - - They conclude that this methoxyflavone enhanced vinblastine uptake by specifically inhibiting drug efflux via P-gp. This may have potential as agent for reversing multidrug resistance or for recovering the bioavailability of certain drugs. The steady-state uptake of [3H]vinblastine was increased by nobiletin in a concentration-dependent manner, although less potently than by HMF or tangeretin. 10734174
MMP-AC0114 BAX BCL2-associated X protein 581 Gastric Cancer AGS - - - - Western blot results showed that expression level of Bax was increased in a dose-dependent manner. 22194772
MMP-AC0114 BCL2L1 BCL2-like 1 598 Gastric Cancer AGS - - - - Western blot results showed that expression level of Bcl-xL was decreased in a dose-dependent manner. 22194772
MMP-AC0114 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Gastric Cancer AGS - - - - Flavonoids caused downregulation of procaspase-3 which consequently increased the activity of caspase-3. 22194772
MMP-AC0114 CCNB1 cyclin B1 891 Gastric Cancer AGS - - - - It reduces the protein level of cyclin B1 in a dose-dependent manner.Decrease of cyclin B1 expression might be a molecular mechanism through which flavonoids induce G2/M arrest. 22194772
MMP-AC0114 CDC25C cell division cycle 25 homolog C (S. pombe) 995 Gastric Cancer AGS - - - - It reduces the protein level of cdc 25c in a dose-dependent manner.Decrease of cdc 25c expression might be a molecular mechanism through which flavonoids induce G2/M arrest. 22194772
MMP-AC0114 CDK1 cyclin-dependent kinase 1 983 Gastric Cancer AGS - - - - It reduces the protein level of cdc 2 in a dose-dependent manner.Decrease of cdc 2 expression might be a molecular mechanism through which flavonoids induce G2/M arrest. 22194772
MMP-AC0114 PARP1 poly (ADP-ribose) polymerase 1 142 Gastric Cancer AGS - - - - During apoptosis, caspases induce PARP cleavage and inactivation and cleavage of PARP helps cellular disassembly and is a marker of cells undergoing apoptosis. 22194772