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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0116 : Puerarin

 
Compound Name  :
Puerarin		  
  Compound Class  : Flavonoid  
  Synonyms  : Puerarin; 3681-99-0; Kakonein; Daidzein-8-C-glucoside; CHEBI:8633;

  
  Compound Extracted from  : Puerarin is extracted / reported from 2 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C21H20O9		  
  Molecular Weight  : 416.4  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 6  
  Hydrogen Bond Acceptor count  : 9  
  Rotational Bond count  : 3  
  TPSA  : 157  
  LogP Value  :

 0

  
 
Lipinski Rule of Five  :
No		  
  Ghose Filter  : No  
  Veber Filter  : No  
  Muegge Filter  :

 No

  
 
PubChem CID  :
5281807		  
  Drugbank ID  : DB12290  
  Super Natural  : -  
  CTD  : C033607  
  HIT  : C0539  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/27717697

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0116 HS578T Breast - - - 46 µM 19013426
MMP-AC0116 MCF-7 Breast - - - 69 µM 19013426
MMP-AC0116 MDA-MB-231 Breast - - - 71 µM 19013426

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0116 BAX BCL2-associated X protein 581 Colon Cancer HT-29 - - - - The bax protein expression level was slightly increased compared to the vehicle control. 16055262
MMP-AC0116 BCL2 B-cell CLL/lymphoma 2 596 Colon Cancer HT-29 - - - - The treatment of the HT-29 cells with the puerarin resulted in a marked decrease of the bcl-2 at protein levels in a dose-dependent manner. 16055262
MMP-AC0116 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Colon Cancer HT-29 - - - - Caspase-3 activity was upregulated after 72 h of treatments with given concentrations of puerarin. 16055262
MMP-AC0116 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Breast Carcinoma MDA-MB-231 - - - - It induced cell apoptosis through a caspase-3-dependent pathway and mediated cell cycle arrest in the G2/M phase. The induction of apoptosis in the breast cancer cell lines by genistein isoflavone confirmed by detection of increased caspase-3 activity in the isoflavone-treated HS578T and MDA-MB-231 cells. 19013426
MMP-AC0116 CASP9 caspase 9, apoptosis-related cysteine peptidase 842 Breast adenocarcinoma MCF-7 - - - - The serum metabolites of Puerariae radix inhibited cell proliferation via an up-regulation of p21/Waf1, p53, caspase-9, and Bax,as revealed by western blottin. 19013426
MMP-AC0116 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1026 Breast adenocarcinoma MCF-7 - - - - The serum metabolites of Puerariae radix inhibited cell proliferation via an up-regulation of p21/Waf1, p53, caspase-9, and Bax, as revealed by western blotting. 19013426
MMP-AC0116 MYC v-myc myelocytomatosis viral oncogene 4609 Colon Cancer HT-29 - - - - The treatment of the HT-29 cells with the puerarin resulted in a marked decrease of the c-myc at protein levels in a dose-dependent manner. 16055262
MMP-AC0116 TP53 tumor protein p53 7157 Breast adenocarcinoma MCF-7 - - - - The serum metabolites of Puerariae radix inhibited cell proliferation via an up-regulation of p21/Waf1, p53, caspase-9, and Bax,as revealed by western blottin. 19013426