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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0147 : Geraniol

 
Compound Name  :
Geraniol		  
  Compound Class  : Terpenoids  
  Synonyms  : GERANIOL; 106-24-1; Lemonol; Geranyl alcohol; trans-Geraniol;

  
  Compound Extracted from  : Geraniol is extracted / reported from 6 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C10H18O		  
  Molecular Weight  : 154.25  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 1  
  Hydrogen Bond Acceptor count  : 1  
  Rotational Bond count  : 4  
  TPSA  : 20.2  
  LogP Value  :

 2.9

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : No  
  Veber Filter  : Yes  
  Muegge Filter  :

 No

  
 
PubChem CID  :
637566		  
  Drugbank ID  : DB14183  
  Super Natural  : 000106241  
  CTD  : C007836  
  HIT  : C0304  
  NCI-60 GI50 data  :

 106-24-1; 68311-14-8

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/22729742

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0147 B16(F10) Skin 150±19 µMol/L - - - 9164984

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0147 BAX BCL2-associated X protein 581 Prostate Cancer PC-3 - - - - The expressions of two CDK inhibitory proteins (p21 and p27) and two pro-apoptotic Bcl-2 family members (Bax and BNIP3) were markedly elevated. 21371438
MMP-AC0147 BCL2 B-cell CLL/lymphoma 2 596 Prostate Cancer PC-3 - - - - geraniol induces apoptosis and cell cycle arrest in vivo 21371438
MMP-AC0147 BCL2 B-cell CLL/lymphoma 2 596 Prostate Cancer PC-3 - - - - The expressions Bcl-2 was reduced in the cells treated with geraniol. 21371438
MMP-AC0147 BCL2L2 BCL2-like 2 599 Prostate Cancer PC-3 - - - - The expressions Bcl-w was reduced in the cells treated with geraniol. 21371438
MMP-AC0147 BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 664 Prostate Cancer PC-3 - - - - The expressions of two CDK inhibitory proteins (p21 and p27) and two pro-apoptotic Bcl-2 family members (Bax and BNIP3) were markedly elevated. 21371438
MMP-AC0147 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Prostate Cancer PC-3 - - - - Caspase-3 activity was increased in relation to concentrations of geraniol in PC-3 cells. 21371438
MMP-AC0147 CCND1 cyclin D1 595 Breast adenocarcinoma MCF-7 - - - - A significant, concentration-dependent decrease in expression of the early G1 phase cyclin D1 was observed in MCF-7 cells treated with geraniol. 15450939
MMP-AC0147 CCNE1 cyclin E1 898 Breast adenocarcinoma MCF-7 - - - - Protein levels of cyclin E decreased significantly in cells treated with geraniol at all concentrationSmM b-ionone. 15450939
MMP-AC0147 CDK1 cyclin-dependent kinase 1 983 Prostate Cancer PC-3 - - - - The expressions CDK1 was reduced in the cells treated with geraniol. 21371438
MMP-AC0147 CDK2 cyclin-dependent kinase 2 1017 Breast adenocarcinoma MCF-7 - - - - Protein levels of CDK 2, decreased significantly in cells treated with geraniol at all concentrations. 15450939
MMP-AC0147 CDK4 cyclin-dependent kinase 4 1019 Prostate Cancer PC-3 - - - - The expressions CDK4 was reduced in the cells treated with geraniol. 21371438
MMP-AC0147 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1026 Prostate Cancer PC-3 - - - - The expressions of two CDK inhibitory proteins (p21 and p27) and two pro-apoptotic Bcl-2 family members (Bax and BNIP3) were markedly elevated. 21371438
MMP-AC0147 CycA Cyclin A 39340 Breast adenocarcinoma MCF-7 - - - - Expression of cyclin A, the S phase CDK 2 activator, decreased significantly following treatment of cells with geraniol. 15450939
MMP-AC0147 CycA Cyclin A 39340 Prostate Cancer PC-3 - - - - The expressions Cyclin A was reduced in the cells treated with geraniol. 21371438
MMP-AC0147 CycB Cyclin B 37618 Prostate Cancer PC-3 - - - - The expressions Cyclin B was reduced in the cells treated with geraniol. 21371438
MMP-AC0147 PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 5715 Prostate Cancer PC-3 - - - - The expressions of two CDK inhibitory proteins (p21 and p27) and two pro-apoptotic Bcl-2 family members (Bax and BNIP3) were markedly elevated. 21371438