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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0157 : Maslinic Acid

 
Compound Name  :
Maslinic Acid		  
  Compound Class  : Terpenoids  
  Synonyms  : Maslinic acid; 4373-41-5; Crategolic acid; Masilinic acid; Maslinic-acid;

  
  Compound Extracted from  : Maslinic Acid is extracted / reported from 4 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C30H48O4		  
  Molecular Weight  : 472.7  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 3  
  Hydrogen Bond Acceptor count  : 4  
  Rotational Bond count  : 1  
  TPSA  : 77.8  
  LogP Value  :

 6.5

  
 
Lipinski Rule of Five  :
No		  
  Ghose Filter  : No  
  Veber Filter  : Yes  
  Muegge Filter  :

 No

  
 
PubChem CID  :
73659		  
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C412811  
  HIT  : -  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/21893403

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0157 MCF-7 Breast - 136.0±2.3 µM - - 17488026
MMP-AC0157 Caco-2 Colon - 15.4±0.4 µM - - 17488026
MMP-AC0157 Hep G2 Liver - 69.1±2.0 µM - - 17488026

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0157 BAX BCL2-associated X protein 581 Colon Cancer HT-29 - - - - We found that in HT29 cells maslinic acid activated the expression of c-Jun NH2-terminal kinase (JNK), thus inducing p53. Treatment of tumor cells with maslinic acid also resulted in an increase in the expression of Bid and Bax, repression of Bcl-2, release of cytochrome-c and an increase in the expression of caspases -9, -3, and -7. Moreover, maslinic acid produced belated caspase-8 activity, thus amplifying the initial mitochondrial apoptotic signaling. 21524306
MMP-AC0157 BCL2 B-cell CLL/lymphoma 2 596 Colon Cancer HT-29 - - - - We found that in HT29 cells maslinic acid activated the expression of c-Jun NH2-terminal kinase (JNK), thus inducing p53. Treatment of tumor cells with maslinic acid also resulted in an increase in the expression of Bid and Bax, repression of Bcl-2, release of cytochrome-c and an increase in the expression of caspases -9, -3, and -7. Moreover, maslinic acid produced belated caspase-8 activity, thus amplifying the initial mitochondrial apoptotic signaling. 21524306
MMP-AC0157 BID BH3 interacting domain death agonist 637 Colon Cancer HT-29 - - - - We found that in HT29 cells maslinic acid activated the expression of c-Jun NH2-terminal kinase (JNK), thus inducing p53. Treatment of tumor cells with maslinic acid also resulted in an increase in the expression of Bid and Bax, repression of Bcl-2, release of cytochrome-c and an increase in the expression of caspases -9, -3, and -7. Moreover, maslinic acid produced belated caspase-8 activity, thus amplifying the initial mitochondrial apoptotic signaling. 21524306
MMP-AC0157 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Colon Cancer HT-29 - - - - We found that in HT29 cells maslinic acid activated the expression of c-Jun NH2-terminal kinase (JNK), thus inducing p53. Treatment of tumor cells with maslinic acid also resulted in an increase in the expression of Bid and Bax, repression of Bcl-2, release of cytochrome-c and an increase in the expression of caspases -9, -3, and -7. Moreover, maslinic acid produced belated caspase-8 activity, thus amplifying the initial mitochondrial apoptotic signaling. 21524306
MMP-AC0157 CASP7 caspase 7, apoptosis-related cysteine peptidase 840 Colon Cancer HT-29 - - - - We found that in HT29 cells maslinic acid activated the expression of c-Jun NH2-terminal kinase (JNK), thus inducing p53. Treatment of tumor cells with maslinic acid also resulted in an increase in the expression of Bid and Bax, repression of Bcl-2, release of cytochrome-c and an increase in the expression of caspases -9, -3, and -7. Moreover, maslinic acid produced belated caspase-8 activity, thus amplifying the initial mitochondrial apoptotic signaling. 21524306
MMP-AC0157 CASP8 caspase 8, apoptosis-related cysteine peptidase 841 Colon Cancer HT-29 - - - - We found that in HT29 cells maslinic acid activated the expression of c-Jun NH2-terminal kinase (JNK), thus inducing p53. Treatment of tumor cells with maslinic acid also resulted in an increase in the expression of Bid and Bax, repression of Bcl-2, release of cytochrome-c and an increase in the expression of caspases -9, -3, and -7. Moreover, maslinic acid produced belated caspase-8 activity, thus amplifying the initial mitochondrial apoptotic signaling. 21524306
MMP-AC0157 CASP9 caspase 9, apoptosis-related cysteine peptidase 842 Colon Cancer HT-29 - - - - We found that in HT29 cells maslinic acid activated the expression of c-Jun NH2-terminal kinase (JNK), thus inducing p53. Treatment of tumor cells with maslinic acid also resulted in an increase in the expression of Bid and Bax, repression of Bcl-2, release of cytochrome-c and an increase in the expression of caspases -9, -3, and -7. Moreover, maslinic acid produced belated caspase-8 activity, thus amplifying the initial mitochondrial apoptotic signaling. 21524306
MMP-AC0157 CYCS cytochrome c 54205 Colon Cancer HT-29 - - - - We found that in HT29 cells maslinic acid activated the expression of c-Jun NH2-terminal kinase (JNK), thus inducing p53. Treatment of tumor cells with maslinic acid also resulted in an increase in the expression of Bid and Bax, repression of Bcl-2, release of cytochrome-c and an increase in the expression of caspases -9, -3, and -7. Moreover, maslinic acid produced belated caspase-8 activity, thus amplifying the initial mitochondrial apoptotic signaling. 21524306
MMP-AC0157 MAPK8 mitogen-activated protein kinase 8 5599 Colon Cancer HT-29 - - - - We found that in HT29 cells maslinic acid activated the expression of c-Jun NH2-terminal kinase (JNK), thus inducing p53. Treatment of tumor cells with maslinic acid also resulted in an increase in the expression of Bid and Bax, repression of Bcl-2, release of cytochrome-c and an increase in the expression of caspases -9, -3, and -7. Moreover, maslinic acid produced belated caspase-8 activity, thus amplifying the initial mitochondrial apoptotic signaling. 21524306
MMP-AC0157 TP53 tumor protein p53 7157 Colon Cancer HT-29 - - - - We found that in HT29 cells maslinic acid activated the expression of c-Jun NH2-terminal kinase (JNK), thus inducing p53. Treatment of tumor cells with maslinic acid also resulted in an increase in the expression of Bid and Bax, repression of Bcl-2, release of cytochrome-c and an increase in the expression of caspases -9, -3, and -7. Moreover, maslinic acid produced belated caspase-8 activity, thus amplifying the initial mitochondrial apoptotic signaling. 21524306