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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0158 : Resveratrol

 
Compound Name  :
Resveratrol		  
  Compound Class  : Flavonoids  
  Synonyms  : resveratrol; 501-36-0; trans-resveratrol; 3,4',5-Trihydroxystilbene; 3,5,4'-Trihydroxystilbene;

  
  Compound Extracted from  : Resveratrol is extracted / reported from 5 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C14H12O3		  
  Molecular Weight  : 228.24  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 3  
  Hydrogen Bond Acceptor count  : 3  
  Rotational Bond count  : 2  
  TPSA  : 60.7  
  LogP Value  :

 3.1

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
445154		  
  Drugbank ID  : DB02709  
  Super Natural  : 000501360  
  CTD  : C059514  
  HIT  : C0247  
  NCI-60 GI50 data  :

 501-36-0

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/29242151

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0158 NGP - 120 然ol/L - - - 17785572
MMP-AC0158 SH-SY5Y Brain 100 然ol/L - - - 17785572
MMP-AC0158 SK-N-AS Bone marrow 70 然ol/L - - - 17785572
MMP-AC0158 MCF-7 Breast 151.8 然 - - - 17848600
MMP-AC0158 MCF-7 Breast 70-150 然 - - - 11895924
MMP-AC0158 MDA-MB-231 Breast 128.8 然 - - - 17848600
MMP-AC0158 Bic-1 Colon 70-150 然 - - - 11895924
MMP-AC0158 SW-480 Colon 70-150 然 - - - 11895924
MMP-AC0158 HCE7 Esophageal 70-150 然 - - - 11895924
MMP-AC0158 HL-60 Haematopoietic and Lymphoid tissue 45 然 (cc-50) - - - 16158945
MMP-AC0158 HL-60 Haematopoietic and Lymphoid tissue >100 然 - - - 12628514
MMP-AC0158 HL-60 Haematopoietic and Lymphoid tissue 70-150 然 - - - 11895924
MMP-AC0158 HSC-2 Head and Neck 155 然 (cc-50) - - - 16158945
MMP-AC0158 Hepa 1c1c7 Liver 29.4 然 - - - 12628514
MMP-AC0158 Seg-1 Lung 70-150 然 - - - 11895924
MMP-AC0158 HSC-3 Oral 288 然 (cc-50) - - - 16158945
MMP-AC0158 HSG Salivary duct 316 然 (cc-50) - - - 16158945

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0158 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Neuroblastoma SK-N-AS - - - - With the treatment of resveratrol Cancer cell showed increased activity of Caspase-3 with increasing drug concentration, suggesting that this downstream component in the intrinsic apoptotic pathway are activated in response to resveratrol treatment. 17785572
MMP-AC0158 CASP8 caspase 8, apoptosis-related cysteine peptidase 841 Neuroblastoma SK-N-AS - - - - Procaspase-8 was cleaved in SK-N-AS cells in a time-dependent manner indicated by the appearance of 43- and 41-kDa intermediate cleavage products and an 18-kDa active product 17785572
MMP-AC0158 CASP9 caspase 9, apoptosis-related cysteine peptidase 842 Neuroblastoma SK-N-AS - - - - With the treatment of resveratrol cancer cell showed increased activity of Caspase-9 with increasing drug concentration, suggesting that this downstream component in the intrinsic apoptotic pathway are activated in response to resveratrol treatment. 17785572
MMP-AC0158 CCNB1 cyclin B1 891 Breast adenocarcinoma MCF-7; - - - - Cyclin B1 expression was detectable in and decreased in all cell lines after treatment with resveratrol. 11895924
MMP-AC0158 CCND1 cyclin D1 595 Colon Cancer SW-480 - - - - Western blot analysis demonstrated that cyclin A and cyclin B1 expression levels did not change initially but decreased after 24 and 48 h of treatment. Interestingly, cyclin D1 expression decreased after only 2 h of treatment and remained diminished after 24 and 48 h of treatment. A lower dose of resveratrol near the IC50 value (100 M) also decreased cyclin D1 expression significantly at 2, 6, 24, and 48 h. 11895924
MMP-AC0158 CTNNBIP1 catenin, beta interacting protein 1 56998 Colon Cancer SW-480 - - - - Beta-Catenin is involved in both colon carcinogenesis and cyclin D1 transcriptional regulation.Cellular extracts were evaluated for -catenin expression after 2, 6, 24, and 48 h of treatment. Western blot analysis demonstrated that Beta-catenin expression did not change initially but decreased after 24 and 48 h of treatment. 11895924
MMP-AC0158 CycA Cyclin A 39340 Colon Cancer SW-480 - - - - Western blot analysis demonstrated that cyclin A and cyclin B1 expression levels did not change initially but decreased after 24 and 48 h of treatment. Interestingly, cyclin D1 expression decreased after only 2 h of treatment and remained diminished after 24 and 48 h of treatment. A lower dose of resveratrol near the IC50 value (100 M) also decreased cyclin D1 expression significantly at 2, 6, 24, and 48 h. 11895924
MMP-AC0158 CYCS cytochrome c 54205 Neuroblastoma NGP - - - - Cytochrome c was released into the cytosol at different times after initiating drug treatment. In NGP cells, cytochrome c release occurred after 24 to 48 h 17785572
MMP-AC0158 DIABLO diablo, IAP-binding mitochondrial protein 56616 Neuroblastoma SK-N-AS - - - - Smac/Diablo was released from the mitochondria with the treatment of compound. 17785572