HOME
BROWSE
FLORA
CONTACT
Botanical Name Plant's Common Name Plant Family   

   MMP-AC0183 : Eupatorin

 
Compound Name  :
Eupatorin		  
  Compound Class  : Flavonoid  
  Synonyms  : Eupatorin; 855-96-9; 3',5-Dihydroxy-4',6,7-trimethoxyflavone; Eupatorine; 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,7-dimethoxy-4H-chromen-4-one;

  
  Compound Extracted from  : Eupatorin is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C18H16O7		  
  Molecular Weight  : 344.3-  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 2  
  Hydrogen Bond Acceptor count  : 7  
  Rotational Bond count  : 4  
  TPSA  : 94.4  
  LogP Value  :

 2.9

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
97214		  
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C103110  
  HIT  : -  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://pubchem.ncbi.nlm.nih.gov/compound/97214

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0183 MCF-10A Breast 50 µM - - - 18454852
MMP-AC0183 MDA-MB-468 Breast 0.5 µM - - - 18454852

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0183 CYP1A1 Cytochrome P450 1543 Breast Carcinoma MDA-MB-468 - - - - Eupatorin was shown to arrest the cell cycle of the CYP1-expressing cell line MDA-MB-468 in G2/M phase. It strongly inhibits proliferation of MDA-MB-468 cells at submicromolar concentrations as a result of CYP1A1 enzyme metabolism 18454852
MMP-AC0183 CYP1B1 Cytochrome P450, family 1, subfamily B, polypeptide 1 1545 Breast Carcinoma MDA-MB-468 - - - - Eupatorin was shown to arrest the cell cycle of the CYP1-expressing cell line MDA-MB-468 in G2/M phase. It strongly inhibits proliferation of MDA-MB-468 cells at submicromolar concentrations as a result of CYP1B1 enzyme metabolism. 18454852