MMP-AC0186 |
NQO1 |
NAD(P)H dehydrogenase, quinone 1 |
1728 |
Colon carcinogenesis |
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Ferulic acid(FA) administration at 100mg/kg dose significantly elevated QR activity in the colonic mucosa or liver (P< 0.02, P< 0<01, respectively). It significantly increased the activities of detoxification enzymes GST and QR in the liver and/or colonic mucosa. Thus, such evidence for the activity on the detoxifying enzymes may also be related to the blocking effect of FA on AOM-induced colon carcinogenesis. |
10893437 |